In vitro interaction between ceftazidime and vancomycin/teicoplanin in the presence of azithromycin against Pseudomonas aeruginosa

Barbara Repetto, Alberto Palenzona, Simone Cagnacci, Eugenio A. Debbia, Anna Marchese

Research output: Contribution to journalArticle

Abstract

Pseudomonas aeruginosa is an opportunistic pathogen, intrinsically resistant to many antibiotics and prone to acquire resistance against many drugs. It is assumed that agents that disorganise the structure of the outer membrane might allow the passage of other drugs into cell. To verify this hypothesis, ceftazidime (CAZ) has been tested in association with glycopeptides (GLYs) and azithromycin (AZI). Time-kill experiments were performed on a representative strain. CAZ in combination with GLYs showed 99, 90 and 10% of CFU/ml reduction in 33.9, 52.5 and 13.6% of the cases, respectively; the addition of AZI increased the incidence of 99% CFU/ml reduction to 42% of the cases. Indifference was the most common finding, and additive/synergism in the other cases. Present findings demonstrated that CAZ favourably reacted with GLYs in the presence of AZI.

Original languageEnglish
Pages (from-to)439-442
Number of pages4
JournalAnnals of Microbiology
Volume57
Issue number3
Publication statusPublished - 2007

Keywords

  • Azithromycin
  • Ceftazidime
  • Drug combination
  • Pseudomonas aeruginosa
  • Selection of resistant strains
  • Time-kill tests
  • Vancomycin

ASJC Scopus subject areas

  • Microbiology
  • Biotechnology

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