Abstract
Pseudomonas aeruginosa is an opportunistic pathogen, intrinsically resistant to many antibiotics and prone to acquire resistance against many drugs. It is assumed that agents that disorganise the structure of the outer membrane might allow the passage of other drugs into cell. To verify this hypothesis, ceftazidime (CAZ) has been tested in association with glycopeptides (GLYs) and azithromycin (AZI). Time-kill experiments were performed on a representative strain. CAZ in combination with GLYs showed 99, 90 and 10% of CFU/ml reduction in 33.9, 52.5 and 13.6% of the cases, respectively; the addition of AZI increased the incidence of 99% CFU/ml reduction to 42% of the cases. Indifference was the most common finding, and additive/synergism in the other cases. Present findings demonstrated that CAZ favourably reacted with GLYs in the presence of AZI.
| Original language | English |
|---|---|
| Pages (from-to) | 439-442 |
| Number of pages | 4 |
| Journal | Annals of Microbiology |
| Volume | 57 |
| Issue number | 3 |
| Publication status | Published - 2007 |
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Keywords
- Azithromycin
- Ceftazidime
- Drug combination
- Pseudomonas aeruginosa
- Selection of resistant strains
- Time-kill tests
- Vancomycin
ASJC Scopus subject areas
- Microbiology
- Biotechnology
Cite this
In vitro interaction between ceftazidime and vancomycin/teicoplanin in the presence of azithromycin against Pseudomonas aeruginosa. / Repetto, Barbara; Palenzona, Alberto; Cagnacci, Simone; Debbia, Eugenio A.; Marchese, Anna.
In: Annals of Microbiology, Vol. 57, No. 3, 2007, p. 439-442.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vitro interaction between ceftazidime and vancomycin/teicoplanin in the presence of azithromycin against Pseudomonas aeruginosa
AU - Repetto, Barbara
AU - Palenzona, Alberto
AU - Cagnacci, Simone
AU - Debbia, Eugenio A.
AU - Marchese, Anna
PY - 2007
Y1 - 2007
N2 - Pseudomonas aeruginosa is an opportunistic pathogen, intrinsically resistant to many antibiotics and prone to acquire resistance against many drugs. It is assumed that agents that disorganise the structure of the outer membrane might allow the passage of other drugs into cell. To verify this hypothesis, ceftazidime (CAZ) has been tested in association with glycopeptides (GLYs) and azithromycin (AZI). Time-kill experiments were performed on a representative strain. CAZ in combination with GLYs showed 99, 90 and 10% of CFU/ml reduction in 33.9, 52.5 and 13.6% of the cases, respectively; the addition of AZI increased the incidence of 99% CFU/ml reduction to 42% of the cases. Indifference was the most common finding, and additive/synergism in the other cases. Present findings demonstrated that CAZ favourably reacted with GLYs in the presence of AZI.
AB - Pseudomonas aeruginosa is an opportunistic pathogen, intrinsically resistant to many antibiotics and prone to acquire resistance against many drugs. It is assumed that agents that disorganise the structure of the outer membrane might allow the passage of other drugs into cell. To verify this hypothesis, ceftazidime (CAZ) has been tested in association with glycopeptides (GLYs) and azithromycin (AZI). Time-kill experiments were performed on a representative strain. CAZ in combination with GLYs showed 99, 90 and 10% of CFU/ml reduction in 33.9, 52.5 and 13.6% of the cases, respectively; the addition of AZI increased the incidence of 99% CFU/ml reduction to 42% of the cases. Indifference was the most common finding, and additive/synergism in the other cases. Present findings demonstrated that CAZ favourably reacted with GLYs in the presence of AZI.
KW - Azithromycin
KW - Ceftazidime
KW - Drug combination
KW - Pseudomonas aeruginosa
KW - Selection of resistant strains
KW - Time-kill tests
KW - Vancomycin
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UR - http://www.scopus.com/inward/citedby.url?scp=35349007543&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:35349007543
VL - 57
SP - 439
EP - 442
JO - Annals of Microbiology
JF - Annals of Microbiology
SN - 1590-4261
IS - 3
ER -