In vitro interaction of Stenotrophomonas maltophilia with human monocyte-derived dendritic cells

Emanuela Roscetto, Laura Vitiello, Rosa Muoio, Amata A. Soriano, Vita D. Iula, Antonio Vollaro, Eliana De Gregorio, Maria R. Catania

Research output: Contribution to journalArticlepeer-review


Stenotrophomonas maltophilia is increasingly identified as an opportunistic pathogen in immunocompromised, cancer and cystic fibrosis (CF) patients. Knowledge on innate immune responses to S. maltophilia and its potential modulation is poor. The present work investigated the ability of 12 clinical S. maltophilia strains (five from CF patients, seven from non-CF patients) and one environmental strain to survive inside human monocyte-derived dendritic cells (DCs). The effects of the bacteria on maturation of and cytokine secretion by DCs were also measured. S. maltophilia strains presented a high degree of heterogeneity in internalization and intracellular replication efficiencies as well as in the ability of S. maltophilia to interfere with normal DCs maturation. By contrast, all S. maltophilia strains were able to activate DCs, as measured by increase in the expression of surface maturation markers and proinflammatory cytokines secretion.

Original languageEnglish
JournalFrontiers in Microbiology
Issue numberJUL
Publication statusPublished - 2015


  • Cystic fibrosis
  • Cytokines secretion
  • DC maturation markers
  • Innate immune response
  • Opportunistic pathogen

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)


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