In vitro leishnmanicidal activity of a monoclonal antibody mimicking a yeast killer toxin

Dianella Savoia, Claudlo Avanzini, Stefania Conti, Valter Magliani, Raffaele Frazzi, Uciano Polonelli

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The microbicidal effect of a monoclonal antiidiotypic antibody, mimicking the activity of a yeast killer toxin, characterized by a wide antimicrobial spectrum, has been evaluated in vitro against two relevant species of protozoan parasites, Leishmania major and Leishmania infantum. The antiidiotypic antibody exerted a significant and dose-dependent antileishmanial activity against parasite promastigotes in comparison to an irrelevant isotype-matched monoclonal antibody. This is the first demonstration that an antibody, which had been already shown to be fungicidal and bactericidal, may also exert a direct microbicidal activity against protozoa.

Original languageEnglish
Pages (from-to)319-323
Number of pages5
JournalJournal of Eukaryotic Microbiology
Volume49
Issue number4
Publication statusPublished - Jul 2002

Fingerprint

Yeast Killer Factor
Protozoa
monoclonal antibodies
Parasites
toxins
Monoclonal Antibodies
Leishmania infantum
yeasts
Leishmania major
parasites
promastigotes
antibodies
Antibodies
anti-infective agents
dosage
In Vitro Techniques

Keywords

  • Antibiotic activity
  • Antibodies
  • Leishmania infantum
  • Leishmania major

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)
  • Applied Microbiology and Biotechnology
  • Microbiology

Cite this

Savoia, D., Avanzini, C., Conti, S., Magliani, V., Frazzi, R., & Polonelli, U. (2002). In vitro leishnmanicidal activity of a monoclonal antibody mimicking a yeast killer toxin. Journal of Eukaryotic Microbiology, 49(4), 319-323.

In vitro leishnmanicidal activity of a monoclonal antibody mimicking a yeast killer toxin. / Savoia, Dianella; Avanzini, Claudlo; Conti, Stefania; Magliani, Valter; Frazzi, Raffaele; Polonelli, Uciano.

In: Journal of Eukaryotic Microbiology, Vol. 49, No. 4, 07.2002, p. 319-323.

Research output: Contribution to journalArticle

Savoia, D, Avanzini, C, Conti, S, Magliani, V, Frazzi, R & Polonelli, U 2002, 'In vitro leishnmanicidal activity of a monoclonal antibody mimicking a yeast killer toxin', Journal of Eukaryotic Microbiology, vol. 49, no. 4, pp. 319-323.
Savoia, Dianella ; Avanzini, Claudlo ; Conti, Stefania ; Magliani, Valter ; Frazzi, Raffaele ; Polonelli, Uciano. / In vitro leishnmanicidal activity of a monoclonal antibody mimicking a yeast killer toxin. In: Journal of Eukaryotic Microbiology. 2002 ; Vol. 49, No. 4. pp. 319-323.
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