In vitro leishnmanicidal activity of a monoclonal antibody mimicking a yeast killer toxin

Dianella Savoia, Claudlo Avanzini, Stefania Conti, Valter Magliani, Raffaele Frazzi, Uciano Polonelli

Research output: Contribution to journalArticlepeer-review

Abstract

The microbicidal effect of a monoclonal antiidiotypic antibody, mimicking the activity of a yeast killer toxin, characterized by a wide antimicrobial spectrum, has been evaluated in vitro against two relevant species of protozoan parasites, Leishmania major and Leishmania infantum. The antiidiotypic antibody exerted a significant and dose-dependent antileishmanial activity against parasite promastigotes in comparison to an irrelevant isotype-matched monoclonal antibody. This is the first demonstration that an antibody, which had been already shown to be fungicidal and bactericidal, may also exert a direct microbicidal activity against protozoa.

Original languageEnglish
Pages (from-to)319-323
Number of pages5
JournalJournal of Eukaryotic Microbiology
Volume49
Issue number4
Publication statusPublished - Jul 2002

Keywords

  • Antibiotic activity
  • Antibodies
  • Leishmania infantum
  • Leishmania major

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)
  • Applied Microbiology and Biotechnology
  • Microbiology

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