In vitro methods for assessing the susceptibility of HIV-1-infected individuals to cysteine protease-mediated activation-induced programmed cell death

Pierre Henkart, Apurva Sarin, Mario Clerici, Gene Shearer

Research output: Contribution to journalArticlepeer-review

Abstract

Calpain has been identified as a component of the biochemical pathway in programmed cell death. Calpain inhibitors are effective in preventing the progression to cell death and can restore cell function. T lymphocytes from HIV infected individuals undergo T cell receptor-triggered programmed cell death which can be treated by calpain inhibitors and immune function can be restored in affected cells. Methods for diagnosing cell populations or individuals susceptible to programmed cell death and for monitoring therapeutic effectiveness are provided.

Original languageEnglish
Pages (from-to)750
Number of pages1
JournalBiotechnology Advances
Volume15
Issue number3-4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Biotechnology

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