In vitro models of the metastatic cascade: From local invasion to extravasation

S. Bersini, J. S. Jeon, Matteo Moretti, R. D. Kamm

Research output: Contribution to journalArticlepeer-review


A crucial event in the metastatic cascade is the extravasation of circulating cancer cells from blood capillaries to the surrounding tissues. The past 5 years have been characterized by a significant evolution in the development of in vitro extravasation models, which moved from traditional transmigration chambers to more sophisticated microfluidic devices, enabling the study of complex cell-cell and cell-matrix interactions in multicellular, controlled environments. These advanced assays could be applied to screen easily and rapidly a broad spectrum of molecules inhibiting cancer cell endothelial adhesion and extravasation, thus contributing to the design of more focused in vivo tests.

Original languageEnglish
Pages (from-to)735-742
Number of pages8
JournalDrug Discovery Today
Issue number6
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Medicine(all)


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