TY - JOUR
T1 - In vitro models of the metastatic cascade
T2 - From local invasion to extravasation
AU - Bersini, S.
AU - Jeon, J. S.
AU - Moretti, Matteo
AU - Kamm, R. D.
PY - 2014
Y1 - 2014
N2 - A crucial event in the metastatic cascade is the extravasation of circulating cancer cells from blood capillaries to the surrounding tissues. The past 5 years have been characterized by a significant evolution in the development of in vitro extravasation models, which moved from traditional transmigration chambers to more sophisticated microfluidic devices, enabling the study of complex cell-cell and cell-matrix interactions in multicellular, controlled environments. These advanced assays could be applied to screen easily and rapidly a broad spectrum of molecules inhibiting cancer cell endothelial adhesion and extravasation, thus contributing to the design of more focused in vivo tests.
AB - A crucial event in the metastatic cascade is the extravasation of circulating cancer cells from blood capillaries to the surrounding tissues. The past 5 years have been characterized by a significant evolution in the development of in vitro extravasation models, which moved from traditional transmigration chambers to more sophisticated microfluidic devices, enabling the study of complex cell-cell and cell-matrix interactions in multicellular, controlled environments. These advanced assays could be applied to screen easily and rapidly a broad spectrum of molecules inhibiting cancer cell endothelial adhesion and extravasation, thus contributing to the design of more focused in vivo tests.
UR - http://www.scopus.com/inward/record.url?scp=84902080037&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84902080037&partnerID=8YFLogxK
U2 - 10.1016/j.drudis.2013.12.006
DO - 10.1016/j.drudis.2013.12.006
M3 - Article
C2 - 24361339
AN - SCOPUS:84902080037
VL - 19
SP - 735
EP - 742
JO - Drug Discovery Today
JF - Drug Discovery Today
SN - 1359-6446
IS - 6
ER -