In vitro models to test orthopedic biomaterials in view of their clinical application in osteoporotic bone

P. Torricelli, M. Fini, G. Giavaresi, Roberto Giardino

Research output: Contribution to journalArticle

Abstract

The development of in vitro cell cultures, in association with in vivo experimentation, greatly improved the characterization of biomaterials for orthopedic devices before their clinical use. In recent years an increasing interest has arisen in the use of both pathological osteoblast cultures and animal models to perform in vitro and in vivo tests on biomaterial behavior. A growing number of prostheses, in fact, are implanted in osteoporotic patients, due to the increasing age of the population. Moreover, the presence of osteoporosis may affect bone-biomaterial osteointegration in these patients. The present paper is a literature review and, after a short description of in vitro studies for characterization of osteoblasts derived from osteoporotic bone, the results of in vitro studies on biomaterial biocompatibility and osteointegration rate in the presence of osteoporotic bone derived osteoblast cultures are reported. Pathological cell culture models are able to demonstrate the different behavior of osteoblasts in response to biomaterials, when comparing normal and pathological conditions.

Original languageEnglish
Pages (from-to)658-663
Number of pages6
JournalInternational Journal of Artificial Organs
Volume27
Issue number8
Publication statusPublished - Aug 2004

Keywords

  • Biomaterial
  • Cell cultures
  • Osteoblasts
  • Osteoporosis

ASJC Scopus subject areas

  • Biophysics

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