In vitro modulation of human monocytes functions by RU 41740 (biostsm®)

S. Sozzani; F. D'Alessandro; F. Capsoni; W. Luini; W. Barcellini; G. Guidi; F. Spreafico

doi:10.1016/0192-0561(88)90084-7

In vitro modulation of human monocytes functions by RU 41740 (biostsm®)

S. Sozzani, F. D'Alessandro, F. Capsoni, W. Luini, W. Barcellini, G. Guidi, F. Spreafico

Research output: Contribution to journal › Article

Abstract

The in vitro effects of RU 41740, a mixture of two glycoproteins extracted from K. pneumoniae and possessing immunomodulatory activity, on human monocyte's cytotoxic activity, migratory capacity and monokine production were investigated. Exposure to RU 41740 in nanogram concentrations was associated with rapid increases in IL-1 and TNF production and marked augmentation in the monocytes' killing of TNF-sensitive targets, whereas killing of TNF-insensitive targets required longer exposures to microgram concentrations of this drug. Using otherwise effective treatment conditions, RU 41740 did not directly affect monocyte's spontaneous and FMLP-induced migration. The possible role of mononuclear cells stimulation and increased production of effector and regulatory monokines in the immunomodulatory activity of this product is addressed.

Original language	English
Pages (from-to)	93-102
Number of pages	10
Journal	International Journal of Immunopharmacology
Volume	10
Issue number	2
DOIs	https://doi.org/10.1016/0192-0561(88)90084-7
Publication status	Published - 1988

ASJC Scopus subject areas

Immunology
Pharmacology

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Sozzani, S., D'Alessandro, F., Capsoni, F., Luini, W., Barcellini, W., Guidi, G., & Spreafico, F. (1988). In vitro modulation of human monocytes functions by RU 41740 (biostsm®). International Journal of Immunopharmacology, 10(2), 93-102. https://doi.org/10.1016/0192-0561(88)90084-7

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abstract = "The in vitro effects of RU 41740, a mixture of two glycoproteins extracted from K. pneumoniae and possessing immunomodulatory activity, on human monocyte's cytotoxic activity, migratory capacity and monokine production were investigated. Exposure to RU 41740 in nanogram concentrations was associated with rapid increases in IL-1 and TNF production and marked augmentation in the monocytes' killing of TNF-sensitive targets, whereas killing of TNF-insensitive targets required longer exposures to microgram concentrations of this drug. Using otherwise effective treatment conditions, RU 41740 did not directly affect monocyte's spontaneous and FMLP-induced migration. The possible role of mononuclear cells stimulation and increased production of effector and regulatory monokines in the immunomodulatory activity of this product is addressed.",

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AU - Sozzani, S.

AU - D'Alessandro, F.

AU - Capsoni, F.

AU - Luini, W.

AU - Barcellini, W.

AU - Guidi, G.

AU - Spreafico, F.

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