IN-VITRO PRODUCTION OF HIV-SPECIFIC ANTIBODY IN CHILDREN AT RISK OF AIDS

Alberto Amadori, Carlo Giaquinto, Franco Zacchello, Anita De Rossi, Georgine Faulkner-Valle, Luigi Chieco-Bianchi

Research output: Contribution to journalArticle

Abstract

To improve on the early diagnosis of human immunodeficiency virus (HIV) infection, 37 children born to HIV-infected mothers and 22 controls were investigated for in-vitro synthesis of IgG antibody directed against HIV components. For 14 of 16 infected children western blot showed HIV-specific IgG in the supernatants of cultures of their peripheral blood lymphocyte cultures. HIV-specific IgG synthesis was detected in cultures from 4 out of 17 seropositive children aged under 15 months with no clinical or laboratory evidence of infection. No HIV-specific IgG production was observed in cultures from 4 uninfected children or 22 controls. The results show that the demonstration of in-vitro production of HIV-specific IgG may help in the early diagnosis of HIV infection in children.

Original languageEnglish
Pages (from-to)852-854
Number of pages3
JournalLancet
Volume331
Issue number8590
DOIs
Publication statusPublished - Apr 16 1988

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Amadori, A., Giaquinto, C., Zacchello, F., De Rossi, A., Faulkner-Valle, G., & Chieco-Bianchi, L. (1988). IN-VITRO PRODUCTION OF HIV-SPECIFIC ANTIBODY IN CHILDREN AT RISK OF AIDS. Lancet, 331(8590), 852-854. https://doi.org/10.1016/S0140-6736(88)91603-0