In vitro production of lymphocyte and granulocyte proliferation inhibitors (chalones?) from living cells

A. T. Maiolo, E. Cazzaniga, A. Cortelezzi, V. De Pangher, P. Foa, L. Lombardi, R. Mozzana, E. E. Polli

Research output: Contribution to journalArticle

Abstract

Media conditioned with viable rat and calf spleen lymphocytes were able to inhibit 3H thymidine uptake by rat thymocytes and the mitogenic response of human lymphocytes to PHA but not bone marrow cells proliferation. The inhibitor appeared to have a molecular weight greater than 50,000 daltons. Media conditioned with rat granulocytes had a similar tissue specific but species non specific inhibitory action. Also human leukemic cells appeared able to produce in vitro an inhibitor of cell proliferation when a certain degree of differentiation was present.

Original languageEnglish
Pages (from-to)235-243
Number of pages9
JournalBollettino dell'Istituto Sieroterapico Milanese
Volume54
Issue number3
Publication statusPublished - 1975

ASJC Scopus subject areas

  • Immunology

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    Maiolo, A. T., Cazzaniga, E., Cortelezzi, A., De Pangher, V., Foa, P., Lombardi, L., Mozzana, R., & Polli, E. E. (1975). In vitro production of lymphocyte and granulocyte proliferation inhibitors (chalones?) from living cells. Bollettino dell'Istituto Sieroterapico Milanese, 54(3), 235-243.