In vitro proliferation of human large granular lymphocytes with v-raf/v-myc recombinant retrovirus

S. Peppoloni, E. Blasi, J. R. Ortaldo, U. R. Rapp, C. Riccardi, L. Varesio

Research output: Contribution to journalArticle

Abstract

The effect of infection with a retrovirus carrying v-raf/v-myc oncogenes (J2 virus) on the in vitro proliferation of human large granular lymphocytes (LGL) was investigated. LGL infected with J2 virus (J2LGL), unlike uninfected cells, grew with a proliferation peak eight days after infection. Such cells retained the morphology and functional properties typical of LGL. Furthermore, 5% of J2LGL produced virus the day after infection, whereas non-virus production was detectable five days later. These data indicate that J2 virus provides a transient mitogenic signal for LGL.

Original languageEnglish
Pages (from-to)1013-1015
Number of pages3
JournalExperientia
Volume44
Issue number11-12
DOIs
Publication statusPublished - Dec 1988

Keywords

  • cell proliferation
  • infection
  • Large granular lymphocytes
  • retrovirus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'In vitro proliferation of human large granular lymphocytes with v-raf/v-myc recombinant retrovirus'. Together they form a unique fingerprint.

  • Cite this