In vitro receptor imaging for characterization of human solid tumors

Silvana Del Vecchio, M. Patrizia Stoppelli, Maria V. Carriero, Rosa Fonti, Ornella Massa, Pei Yong Li, Gerardo Botti, Maria Cerra, Giuseppe D'Aiuto, Giuseppe Esposito, Marco Salvatore

Research output: Contribution to journalArticlepeer-review

Abstract

Since many of the factors involved in tumor growth and progression act through a receptor-mediated mechanism, we applied in vitro receptor imaging techniques to study the intratumoral distribution and concentration of receptor-molecules having experimental biological relevance in such processes. Here we summarize the results of a study concerning the role of urokinase receptor (uPAR) in the acquisition of an invasive phenotype by tumor cells. Independently of the system studied, we demonstrated that in vitro receptor imaging techniques can be used to define the biological characteristics of human solid tumors and can contribute to clarify the complex network of ligand/receptor interactions leading to tumor spread.

Original languageEnglish
Pages (from-to)771-774
Number of pages4
JournalNuclear Medicine and Biology
Volume21
Issue number5
DOIs
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

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