In vitro release of activin A from human normal and pathological thyroid tissues

P. S. Morpurgo, A. Corsi, S. Corbetta, L. Vicentini, A. Spada

Research output: Contribution to journalArticle

Abstract

Activin A is a dimeric glycoprotein belonging to the transforming growth factor β (TGF-β) superfamily characterized by the ability to affect FSH secretion. Activin A was originally indicated as a gonadal product but the expression of activin A has been successively identified in several different tissues, including the thyroid gland. The aim of this study was to evaluate the release of activin A from human normal and pathological thyroid tissues in culture. Activin A concentration was evaluated in media obtained from primary culture of perinodular normal tissues (no.=2), hyperplastic hyperfunctioning thyroid tissues due to Graves' disease (no.=3) and autonomous thyroid adenomas (no.=3). Detectable levels of activin A were found in the incubation media from all tissues, without significant differences between normal and pathological samples. We conclude that activin A is secreted by follicle thyroid cells in normal and pathological conditions.

Original languageEnglish
JournalJournal of Endocrinological Investigation
Volume24
Issue number8
Publication statusPublished - 2001

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Keywords

  • Activin A
  • Human thyroid

ASJC Scopus subject areas

  • Endocrinology

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