In vitro selection of HIV and CMV specific T-lymphocytes

G. Li Pira, L. Bottone, F. Ivaldi, A. Ricciardi, G. Barbano, F. Manca

Research output: Contribution to journalArticlepeer-review

Abstract

CMV and HIV produce life-long infections. During CMV infection, cellular responses mediated by virus specific CD8 and CD4 lymphocytes are effective, while during HIV infection cellular responses are ineffective in the long run. In recent years, much work has been carried out to better characterize such responses by using different methodologies to define the fine epitope specificity, the frequency and the function of specific T-cells. These studies have diagnostic and therapeutic implications. In fact, monitoring of specific lymphocytes may help define the immune status of the patients for therapeutic interventions. Identification of CD8 and CD4 epitopes allows the use of relevant peptides for lymphocyte stimulation or for vaccine development. Enumeration of specific cells permits a quantitative estimate of the immune response. In vitro selection provides large numbers of virus specific T-cells for studies on clonal composition, on epitope mapping and on HLA restriction as well as for therapeutic immunoreconstitution with ex vivo expanded T-cells.

Original languageEnglish
Pages (from-to)183-186
Number of pages4
JournalJournal of Biological Regulators and Homeostatic Agents
Volume18
Issue number2
Publication statusPublished - Apr 2004

Keywords

  • CD4 cells
  • CD8 cells epitopes
  • Cytomegalovirus
  • HIV
  • T-cell lines

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)

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