In vitro stability of Cucumber mosaic virus nanoparticles carrying a Hepatitis C virus-derived epitope under simulated gastrointestinal conditions and in vivo efficacy of an edible vaccine

M. Nuzzaci, A. Vitti, V. Condelli, M. T. Lanorte, C. Tortorella, D. Boscia, P. Piazzolla, G. Piazzolla

Research output: Contribution to journalArticle

Abstract

The Cucumber mosaic virus (CMV) is an isodiametric plant virus with an extremely wide host range, present worldwide. CMV chimeric particles (R9-CMV), engineered to express a 27-aa synthetic peptide derived from Hepatitis C virus (HCV), were demonstrated to be stable under simulated gastric and intestinal conditions. Then the possibility of inducing a humoral immune response in rabbits fed with R9-CMV infected lettuce plants was demonstrated, suggesting that this system could function as a confirming tool of a bioreactor for the production of a stable edible vaccine against HCV.

Original languageEnglish
Pages (from-to)211-215
Number of pages5
JournalJournal of Virological Methods
Volume165
Issue number2
DOIs
Publication statusPublished - May 2010

Keywords

  • Chimeric CMV particles
  • Edible vaccine
  • HCV

ASJC Scopus subject areas

  • Virology

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