Sintesi di interleuchina 2 (IL-2) in vitro da parte di T-linfociti estratti da timoma linfoepiteliale. Purificazione e caratterizzazione biochimica.

Translated title of the contribution: In vitro synthesis of interleukin 2 (IL-2) by T lymphocytes extracted from a lymphoepithelial thymoma. Purification and biochemical characterization

M. Ponzoni, M. Fenice, P. Montaldo, G. P. Tonini, P. Cornaglia-Ferraris

Research output: Contribution to journalArticlepeer-review

Abstract

T (E+) lymphocytes purified from lymphoepithelial thymoma surgically removed from an asymptomatic 12 yrs old girl were cultured in presence of PHA-P; culture supernatant contained a T cell growth factor (IL-2) biochemically different from that purifiable from supernatants of normal T cells. Differences in molecular weight, isoelectric point and ion exchange elution pattern would allow to compare this abnormal IL-2, (named Thy-IL-2 from Thymus) to that already characterized from the HUT 102 T cell line (L-TCGF peak II). A comparison of biochemical properties of Thy-IL-2 and normal IL-2 (N-IL-2) is also presented; the biological significance of such differences are discussed.

Translated title of the contributionIn vitro synthesis of interleukin 2 (IL-2) by T lymphocytes extracted from a lymphoepithelial thymoma. Purification and biochemical characterization
Original languageItalian
Pages (from-to)12-24
Number of pages13
JournalBollettino dell'Istituto Sieroterapico Milanese
Volume64
Issue number1
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Immunology

Fingerprint

Dive into the research topics of 'In vitro synthesis of interleukin 2 (IL-2) by T lymphocytes extracted from a lymphoepithelial thymoma. Purification and biochemical characterization'. Together they form a unique fingerprint.

Cite this