In vitro t cell function, delayed-type hypersensitivity skin testing, and cd4+ t cell subset phenotyping independently predict survival time in patients infected with human immunodeficiency Virus

Matthew J. Dolan, Mario Clerici, Stephen P. Blatt, Craig W. Hendrix, Gregory P. Melcher, R. Neal Boswell, Theodore M. Freeman, William Ward, Rex Hensley, Gene M. Shearer

Research output: Contribution to journalArticle

Abstract

Human immunodeficiency virus type 1 (HIV-1)-infected patients (n = 335) in the US Air Force HIV Natural History Program were followed for 3 years (mean) after skin testing, immunophenotyping of CD4+ cell subsets, and measurement of in vitro interleukin-2 production after stimulation by phytohemagglutinin, alloantigens, tetanus toxoid, and influenza A virus. The T cell functional assay predicted survival time (P + T cells (P =.001), the percentage of CD4+CD29+ cells (P =.06), and the number of reactive skin tests (P + cell count.

Original languageEnglish
Pages (from-to)79-87
Number of pages9
JournalJournal of Infectious Diseases
Volume172
Issue number1
DOIs
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Immunology
  • Public Health, Environmental and Occupational Health

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