In vivo 19F MR imaging and spectroscopy for the BNCT optimization

P. Porcari, S. Capuani, E. D'Amore, M. Lecce, A. La Bella, F. Fasano, L. M. Migneco, R. Campanella, B. Maraviglia, F. S. Pastore

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The aim of this study was to evaluate in vivo the boron biodistribution and pharmacokinetics of 4-borono-2-fluorophenylalanine (19F-BPA) using 19F MR Imaging (19F MRI) and Spectroscopy (19F MRS). The correlation between the results obtained by both techniques, 19F MRI on rat brain and 19F MRS on blood samples, showed the maximum 19F-BPA uptake in C6 glioma model at 2.5 h after infusion determining the optimal irradiation time. Moreover, the effect of L-DOPA as potential enhancer of 19F-BPA tumour intake was assessed using 19F MRI.

Original languageEnglish
JournalApplied Radiation and Isotopes
Volume67
Issue number7-8 SUPPL.
DOIs
Publication statusPublished - Jul 2009

Fingerprint

Boron
Glioma
Spectrum Analysis
Magnetic Resonance Spectroscopy
Pharmacokinetics
optimization
Brain
spectroscopy
rats
blood
brain
Neoplasms
boron
tumors
irradiation
4-borono-2-fluorophenylalanine
Fluorine-19 Magnetic Resonance Imaging

Keywords

  • F MRI
  • F MRS
  • F-BPA
  • Animal model
  • BNCT
  • BPA
  • C6 glioma
  • L-DOPA
  • MRI
  • Rat brain

ASJC Scopus subject areas

  • Radiation
  • Medicine(all)

Cite this

Porcari, P., Capuani, S., D'Amore, E., Lecce, M., La Bella, A., Fasano, F., ... Pastore, F. S. (2009). In vivo 19F MR imaging and spectroscopy for the BNCT optimization. Applied Radiation and Isotopes, 67(7-8 SUPPL.). https://doi.org/10.1016/j.apradiso.2009.03.065

In vivo 19F MR imaging and spectroscopy for the BNCT optimization. / Porcari, P.; Capuani, S.; D'Amore, E.; Lecce, M.; La Bella, A.; Fasano, F.; Migneco, L. M.; Campanella, R.; Maraviglia, B.; Pastore, F. S.

In: Applied Radiation and Isotopes, Vol. 67, No. 7-8 SUPPL., 07.2009.

Research output: Contribution to journalArticle

Porcari, P, Capuani, S, D'Amore, E, Lecce, M, La Bella, A, Fasano, F, Migneco, LM, Campanella, R, Maraviglia, B & Pastore, FS 2009, 'In vivo 19F MR imaging and spectroscopy for the BNCT optimization', Applied Radiation and Isotopes, vol. 67, no. 7-8 SUPPL.. https://doi.org/10.1016/j.apradiso.2009.03.065
Porcari P, Capuani S, D'Amore E, Lecce M, La Bella A, Fasano F et al. In vivo 19F MR imaging and spectroscopy for the BNCT optimization. Applied Radiation and Isotopes. 2009 Jul;67(7-8 SUPPL.). https://doi.org/10.1016/j.apradiso.2009.03.065
Porcari, P. ; Capuani, S. ; D'Amore, E. ; Lecce, M. ; La Bella, A. ; Fasano, F. ; Migneco, L. M. ; Campanella, R. ; Maraviglia, B. ; Pastore, F. S. / In vivo 19F MR imaging and spectroscopy for the BNCT optimization. In: Applied Radiation and Isotopes. 2009 ; Vol. 67, No. 7-8 SUPPL.
@article{ea416e9c5d324f4c87c40c40ff40adf6,
title = "In vivo 19F MR imaging and spectroscopy for the BNCT optimization",
abstract = "The aim of this study was to evaluate in vivo the boron biodistribution and pharmacokinetics of 4-borono-2-fluorophenylalanine (19F-BPA) using 19F MR Imaging (19F MRI) and Spectroscopy (19F MRS). The correlation between the results obtained by both techniques, 19F MRI on rat brain and 19F MRS on blood samples, showed the maximum 19F-BPA uptake in C6 glioma model at 2.5 h after infusion determining the optimal irradiation time. Moreover, the effect of L-DOPA as potential enhancer of 19F-BPA tumour intake was assessed using 19F MRI.",
keywords = "F MRI, F MRS, F-BPA, Animal model, BNCT, BPA, C6 glioma, L-DOPA, MRI, Rat brain",
author = "P. Porcari and S. Capuani and E. D'Amore and M. Lecce and {La Bella}, A. and F. Fasano and Migneco, {L. M.} and R. Campanella and B. Maraviglia and Pastore, {F. S.}",
year = "2009",
month = "7",
doi = "10.1016/j.apradiso.2009.03.065",
language = "English",
volume = "67",
journal = "Applied Radiation and Isotopes",
issn = "0969-8043",
publisher = "Elsevier Limited",
number = "7-8 SUPPL.",

}

TY - JOUR

T1 - In vivo 19F MR imaging and spectroscopy for the BNCT optimization

AU - Porcari, P.

AU - Capuani, S.

AU - D'Amore, E.

AU - Lecce, M.

AU - La Bella, A.

AU - Fasano, F.

AU - Migneco, L. M.

AU - Campanella, R.

AU - Maraviglia, B.

AU - Pastore, F. S.

PY - 2009/7

Y1 - 2009/7

N2 - The aim of this study was to evaluate in vivo the boron biodistribution and pharmacokinetics of 4-borono-2-fluorophenylalanine (19F-BPA) using 19F MR Imaging (19F MRI) and Spectroscopy (19F MRS). The correlation between the results obtained by both techniques, 19F MRI on rat brain and 19F MRS on blood samples, showed the maximum 19F-BPA uptake in C6 glioma model at 2.5 h after infusion determining the optimal irradiation time. Moreover, the effect of L-DOPA as potential enhancer of 19F-BPA tumour intake was assessed using 19F MRI.

AB - The aim of this study was to evaluate in vivo the boron biodistribution and pharmacokinetics of 4-borono-2-fluorophenylalanine (19F-BPA) using 19F MR Imaging (19F MRI) and Spectroscopy (19F MRS). The correlation between the results obtained by both techniques, 19F MRI on rat brain and 19F MRS on blood samples, showed the maximum 19F-BPA uptake in C6 glioma model at 2.5 h after infusion determining the optimal irradiation time. Moreover, the effect of L-DOPA as potential enhancer of 19F-BPA tumour intake was assessed using 19F MRI.

KW - F MRI

KW - F MRS

KW - F-BPA

KW - Animal model

KW - BNCT

KW - BPA

KW - C6 glioma

KW - L-DOPA

KW - MRI

KW - Rat brain

UR - http://www.scopus.com/inward/record.url?scp=67649612520&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649612520&partnerID=8YFLogxK

U2 - 10.1016/j.apradiso.2009.03.065

DO - 10.1016/j.apradiso.2009.03.065

M3 - Article

C2 - 19375924

AN - SCOPUS:67649612520

VL - 67

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

SN - 0969-8043

IS - 7-8 SUPPL.

ER -