In vivo 31P spectroscopy study of treated and untreated recovery of rat partial brain ischemia

M. A. Macri, R. Campanella, F. De Luca, A. Montalbano, F. Taggi, B. Maraviglia

Research output: Contribution to journalArticlepeer-review

Abstract

Quantitative 31P NMR was used to follow the time variation of the hypometabolic response to hypoxic partial ischemia in an animal model. The purpose of the study was to establish the value of this repeated spectroscopy operating by means of a surface coil. It aimed at determining whether a therapeutic intervention could influence the transient changes occurring during the insult or early recovery. A pharmacological substance was thus used during a reversible forebrain ischemia, induced by a combination of vascular occlusion and mild hypoxia in two groups of rats. As an available and convenient example, L-carnitine was chosen. Statistical analysis of the experimental results revealed a significant difference of the P(i) and PCr levels between treated and untreated animals.

Original languageEnglish
Pages (from-to)542-547
Number of pages6
JournalMagnetic Resonance in Medicine
Volume34
Issue number4
DOIs
Publication statusPublished - 1995

Keywords

  • P NMR spectroscopy
  • hypoxic ischemia
  • L-carnitine
  • reperfusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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