In vivo activated cord blood lymphocytes express high affinity lnterleukin-2 receptor: Evaluation of their responsiveness to in vitro stimulation with recombinant lnterleukin-2

D. Montagna, A. Moretta, M. Marconi, G. Mingrat, A. Gasparoni, M. Giarola, R. Maccario

Research output: Contribution to journalArticle

Abstract

We report the phenotypical and functional characterization of a cord blood mononuclear lymphocyte subset (CBMC) which expresses the p55 chain of interleukin-2 receptor(IL-2R. CD25). The great majority of CD25-positive CBMC are activated CD3-positivc T lymphocytes in that most of them are HLA-DR-pos-itive. coexpress both CD4 and CD8 antigens and at least a part of them display high affinity IL-2R. In keeping with the expression of both chains of IL-2R (p55 and p75). enriched CD25-positive CBMC arc able to display strong IL-2-induced proliferation and lymphokine-activated killing activity. The percentage of CD25-positive cells is higher in cord blood than in adult peripheral blood and their presence could be peculiarly important in the neonatal period, when specific T-cell-mediated immune responses are still on their way to full maturation.

Original languageEnglish
Pages (from-to)385-394
Number of pages10
JournalNeonatology
Volume62
Issue number6
DOIs
Publication statusPublished - 1992

Keywords

  • Cord blood lymphocytes
  • IL-2 receptor
  • T lymphocytes

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

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