IN-vivo activation of circulating inactive renin by the ischemic kidney in man

N. Glorioso, P. Madeddu, P. Dessí Fulgheri, F. Cocco, G. Sanna, C. Fiori, S. Dettori, A. Rappelli

Research output: Contribution to journalArticle

Abstract

The role of the kidney as a possible source or as activator of inactive renin was studied in 22 patients with Essential Hypertension (EH) and in 20 patients with Unilateral Renal Artery Stenosis (RAS). Active and inactive renin (trypsin activation) were measured in blood samples taken simultaneously from both renal veins and from a peripheral artery during acute diuretic stimulation induced by furosemide 40 mg i.v. In EH pts active and trypsin-activated renin were significantly higher in both renal veins than in arterial blood (P

Original languageEnglish
Pages (from-to)951-961
Number of pages11
JournalClinical and Experimental Hypertension
VolumeA4
Issue number6
DOIs
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

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    Glorioso, N., Madeddu, P., Fulgheri, P. D., Cocco, F., Sanna, G., Fiori, C., Dettori, S., & Rappelli, A. (1982). IN-vivo activation of circulating inactive renin by the ischemic kidney in man. Clinical and Experimental Hypertension, A4(6), 951-961. https://doi.org/10.3109/10641968209060764