In vivo activation of macrophages but not natural killer cells by picolinic acid (PLA)

R. Ruffmann, R. D. Welker, T. Saito, M. A. Chirigos, L. Varesio

Research output: Contribution to journalArticle


Intraperitoneal injection of PLA into C57BL/6 mice induced high levels of macrophage-mediated cytostatic activity. Maximal cytostatic activity was found 3 days after injection of 100 mg/kg of PLA. In contrast, natural killer cell activity was not affected by PLA. Thus, PLA selectively modulates macrophage activity without influencing NK activity.

Original languageEnglish
Pages (from-to)291-304
Number of pages14
JournalJournal of Immunopharmacology
Issue number4
Publication statusPublished - 1984


ASJC Scopus subject areas

  • Immunology
  • Toxicology
  • Pharmacology

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