In vivo activation of macrophages but not natural killer cells by picolinic acid (PLA)

R. Ruffmann, R. D. Welker, T. Saito, M. A. Chirigos, L. Varesio

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Intraperitoneal injection of PLA into C57BL/6 mice induced high levels of macrophage-mediated cytostatic activity. Maximal cytostatic activity was found 3 days after injection of 100 mg/kg of PLA. In contrast, natural killer cell activity was not affected by PLA. Thus, PLA selectively modulates macrophage activity without influencing NK activity.

Original languageEnglish
Pages (from-to)291-304
Number of pages14
JournalJournal of Immunopharmacology
Volume6
Issue number4
Publication statusPublished - 1984

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Macrophage Activation
Macrophages
Natural Killer Cells
Chemical activation
Cytostatic Agents
Intraperitoneal Injections
Inbred C57BL Mouse
Injections
picolinic acid

ASJC Scopus subject areas

  • Immunology
  • Toxicology
  • Pharmacology

Cite this

In vivo activation of macrophages but not natural killer cells by picolinic acid (PLA). / Ruffmann, R.; Welker, R. D.; Saito, T.; Chirigos, M. A.; Varesio, L.

In: Journal of Immunopharmacology, Vol. 6, No. 4, 1984, p. 291-304.

Research output: Contribution to journalArticle

Ruffmann, R, Welker, RD, Saito, T, Chirigos, MA & Varesio, L 1984, 'In vivo activation of macrophages but not natural killer cells by picolinic acid (PLA)', Journal of Immunopharmacology, vol. 6, no. 4, pp. 291-304.
Ruffmann, R. ; Welker, R. D. ; Saito, T. ; Chirigos, M. A. ; Varesio, L. / In vivo activation of macrophages but not natural killer cells by picolinic acid (PLA). In: Journal of Immunopharmacology. 1984 ; Vol. 6, No. 4. pp. 291-304.
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