Abstract
Purpose: To assess the effectiveness of spectral domain optical coherence tomography (SD-OCT) in providing in vivo measurements of iris thickness in healthy and pathological subjects. Methods: 14 healthy volunteers and 14 patients with unilateral Fuchs' uveitis were enrolled in the study. The two groups were comparable for age, gender and race. Each subject underwent complete clinical examination and anterior segment SD-OCT imaging in both eyes. SD-OCT scans of the iris were performed following a cross-sectional pattern. Iris thickness values were obtained using a purposely developed software-based analysis of OCT images. Measurements were carried out twice by two trained independent operators to assess intraobserver and interobserver repeatability. Analysis of iris thickness was conducted in four main quadrants: superior, inferior, nasal and temporal. Iris thickness values from normal subjects were compared with the ones measured in the affected and fellow eyes of patients with Fuchs' uveitis. Results: Iris thickness measurements showed good intraobserver and interobserver repeatability (intraclass correlation coeffi cient >0.971). Superior and temporal iris sectors showed respectively thickest and thinnest values in all groups. In healthy eyes, iris thickness ranged from 327.92±37.29 μm temporally to 405.25 ±48.49 μm superiorly. Iris thickness measurements in the affected eyes of Fuchs' uveitis patients ranged from 285.48±56.02 μm temporally to 376.12±60.97 μm superiorly. Multiple comparison analysis showed iris thickness values to be signi ficantly lower in eyes affected by Fuchs' uveitis than both in fellow eyes (p
| Original language | English |
|---|---|
| Pages (from-to) | 1245-1249 |
| Number of pages | 5 |
| Journal | British Journal of Ophthalmology |
| Volume | 98 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2014 |
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ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
Cite this
In vivo analysis of the iris thickness by spectral domain optical coherence tomography. / Invernizzi, Alessandro; Cigada, Mario; Savoldi, Luisa; Cavuto, Silvio; Fontana, Luigi; Cimino, Luca.
In: British Journal of Ophthalmology, Vol. 98, No. 9, 2014, p. 1245-1249.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vivo analysis of the iris thickness by spectral domain optical coherence tomography
AU - Invernizzi, Alessandro
AU - Cigada, Mario
AU - Savoldi, Luisa
AU - Cavuto, Silvio
AU - Fontana, Luigi
AU - Cimino, Luca
PY - 2014
Y1 - 2014
N2 - Purpose: To assess the effectiveness of spectral domain optical coherence tomography (SD-OCT) in providing in vivo measurements of iris thickness in healthy and pathological subjects. Methods: 14 healthy volunteers and 14 patients with unilateral Fuchs' uveitis were enrolled in the study. The two groups were comparable for age, gender and race. Each subject underwent complete clinical examination and anterior segment SD-OCT imaging in both eyes. SD-OCT scans of the iris were performed following a cross-sectional pattern. Iris thickness values were obtained using a purposely developed software-based analysis of OCT images. Measurements were carried out twice by two trained independent operators to assess intraobserver and interobserver repeatability. Analysis of iris thickness was conducted in four main quadrants: superior, inferior, nasal and temporal. Iris thickness values from normal subjects were compared with the ones measured in the affected and fellow eyes of patients with Fuchs' uveitis. Results: Iris thickness measurements showed good intraobserver and interobserver repeatability (intraclass correlation coeffi cient >0.971). Superior and temporal iris sectors showed respectively thickest and thinnest values in all groups. In healthy eyes, iris thickness ranged from 327.92±37.29 μm temporally to 405.25 ±48.49 μm superiorly. Iris thickness measurements in the affected eyes of Fuchs' uveitis patients ranged from 285.48±56.02 μm temporally to 376.12±60.97 μm superiorly. Multiple comparison analysis showed iris thickness values to be signi ficantly lower in eyes affected by Fuchs' uveitis than both in fellow eyes (p
AB - Purpose: To assess the effectiveness of spectral domain optical coherence tomography (SD-OCT) in providing in vivo measurements of iris thickness in healthy and pathological subjects. Methods: 14 healthy volunteers and 14 patients with unilateral Fuchs' uveitis were enrolled in the study. The two groups were comparable for age, gender and race. Each subject underwent complete clinical examination and anterior segment SD-OCT imaging in both eyes. SD-OCT scans of the iris were performed following a cross-sectional pattern. Iris thickness values were obtained using a purposely developed software-based analysis of OCT images. Measurements were carried out twice by two trained independent operators to assess intraobserver and interobserver repeatability. Analysis of iris thickness was conducted in four main quadrants: superior, inferior, nasal and temporal. Iris thickness values from normal subjects were compared with the ones measured in the affected and fellow eyes of patients with Fuchs' uveitis. Results: Iris thickness measurements showed good intraobserver and interobserver repeatability (intraclass correlation coeffi cient >0.971). Superior and temporal iris sectors showed respectively thickest and thinnest values in all groups. In healthy eyes, iris thickness ranged from 327.92±37.29 μm temporally to 405.25 ±48.49 μm superiorly. Iris thickness measurements in the affected eyes of Fuchs' uveitis patients ranged from 285.48±56.02 μm temporally to 376.12±60.97 μm superiorly. Multiple comparison analysis showed iris thickness values to be signi ficantly lower in eyes affected by Fuchs' uveitis than both in fellow eyes (p
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U2 - 10.1136/bjophthalmol-2013-304481
DO - 10.1136/bjophthalmol-2013-304481
M3 - Article
C2 - 24735773
AN - SCOPUS:84906937032
VL - 98
SP - 1245
EP - 1249
JO - British Journal of Ophthalmology
JF - British Journal of Ophthalmology
SN - 0007-1161
IS - 9
ER -