In vivo and in vitro evaluation of the influence of aromatic retinoid RO 10-9359 and of its metabolite TMMP-RA, RO 10-1670 on polymorphonuclear leukocyte and lymphocyte functions in psoriatic subjects

M. Marconi, D. Montagna, C. Alberini

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Lymphocytes and polymorphonuclear leukocytes functions of 10 psoriatic patients treated with aromatic retinoid RO 10-9359 were investigated. No changes of OK-T subpopulations were observed before, during (days 7, 14) and at the end of treatment (day 21). No alterations of PMNs functions investigated (chemotaxis, bactericidal activity, phagocytosis, NBT test reduction, respiratory burst) before, during and after treatment were observed. Lymphocyte responsiveness to polyclonal mitogens (PHA, ConA, PWM) were basically normal and decreased during treatment. No influences of the metabolite RO 10-1670 on PMNs chemotaxis in vitro could be shown.

Original languageEnglish
Pages (from-to)47-49
Number of pages3
JournalActa Dermato-Venereologica
Volume64
Issue numberSUPPL. 113
Publication statusPublished - 1984

Fingerprint

Retinoids
Neutrophils
Chemotaxis
Lymphocytes
evaluation
Respiratory Burst
Mitogens
Phagocytosis
Therapeutics
In Vitro Techniques
1-methyl-4-(methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine
Evaluation

ASJC Scopus subject areas

  • Dermatology

Cite this

@article{7926e13fbf26475ab848c7530b742957,
title = "In vivo and in vitro evaluation of the influence of aromatic retinoid RO 10-9359 and of its metabolite TMMP-RA, RO 10-1670 on polymorphonuclear leukocyte and lymphocyte functions in psoriatic subjects",
abstract = "Lymphocytes and polymorphonuclear leukocytes functions of 10 psoriatic patients treated with aromatic retinoid RO 10-9359 were investigated. No changes of OK-T subpopulations were observed before, during (days 7, 14) and at the end of treatment (day 21). No alterations of PMNs functions investigated (chemotaxis, bactericidal activity, phagocytosis, NBT test reduction, respiratory burst) before, during and after treatment were observed. Lymphocyte responsiveness to polyclonal mitogens (PHA, ConA, PWM) were basically normal and decreased during treatment. No influences of the metabolite RO 10-1670 on PMNs chemotaxis in vitro could be shown.",
author = "M. Marconi and D. Montagna and C. Alberini",
year = "1984",
language = "English",
volume = "64",
pages = "47--49",
journal = "Acta Borealia",
issn = "0001-5555",
publisher = "Society for the Publication of Acta Dermato-Venereologica",
number = "SUPPL. 113",

}

TY - JOUR

T1 - In vivo and in vitro evaluation of the influence of aromatic retinoid RO 10-9359 and of its metabolite TMMP-RA, RO 10-1670 on polymorphonuclear leukocyte and lymphocyte functions in psoriatic subjects

AU - Marconi, M.

AU - Montagna, D.

AU - Alberini, C.

PY - 1984

Y1 - 1984

N2 - Lymphocytes and polymorphonuclear leukocytes functions of 10 psoriatic patients treated with aromatic retinoid RO 10-9359 were investigated. No changes of OK-T subpopulations were observed before, during (days 7, 14) and at the end of treatment (day 21). No alterations of PMNs functions investigated (chemotaxis, bactericidal activity, phagocytosis, NBT test reduction, respiratory burst) before, during and after treatment were observed. Lymphocyte responsiveness to polyclonal mitogens (PHA, ConA, PWM) were basically normal and decreased during treatment. No influences of the metabolite RO 10-1670 on PMNs chemotaxis in vitro could be shown.

AB - Lymphocytes and polymorphonuclear leukocytes functions of 10 psoriatic patients treated with aromatic retinoid RO 10-9359 were investigated. No changes of OK-T subpopulations were observed before, during (days 7, 14) and at the end of treatment (day 21). No alterations of PMNs functions investigated (chemotaxis, bactericidal activity, phagocytosis, NBT test reduction, respiratory burst) before, during and after treatment were observed. Lymphocyte responsiveness to polyclonal mitogens (PHA, ConA, PWM) were basically normal and decreased during treatment. No influences of the metabolite RO 10-1670 on PMNs chemotaxis in vitro could be shown.

UR - http://www.scopus.com/inward/record.url?scp=0021735875&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021735875&partnerID=8YFLogxK

M3 - Article

VL - 64

SP - 47

EP - 49

JO - Acta Borealia

JF - Acta Borealia

SN - 0001-5555

IS - SUPPL. 113

ER -