In vivo and in vitro interference of phosphatidylserine liposomes on prolactin secretion in the rat

P. L. Canonico, L. Annunziato, G. Toffano, R. Bernardini, S. Stanzani, M. Foti, G. Clementi, F. Drago, U. Scapagnini

Research output: Contribution to journalArticlepeer-review


The effect of sonicated suspensions of phosphatidylserine (PS), an acidic phospholipid, was investigated on prolactin secretion utilizing in vivo and in vitro approaches. Acute and chronic administration of PS reduced plasma prolactin levels during different phases of circadian rhythms. The phospholipid was able to inhibit the plasma prolactin surge, which occurs in cycling female rats on the afternoon of proestrus. The time course of PS on prolactin secretion was characterized by a short latency (15 min) and a long duration of action (6 h). In rats with hypothalamic deafferentation PS partially reduced the increase of circulating prolactin induced by pretreatment with α-methyltyrosine. An inhibition of prolactin release was observed if anterior pituitary glands were incubated in presence of PS. This effect was prevented by the addition of the dopamine antagonist sulpiride to the medium. In conclusion, PS decreases prolactin secretion both in vivo and in vitro. The inhibition of the hormone secretion appears to be due to the action of PS at the level of the pituitary; however, a concomitant stimulatory action on the turnover of the tuberoinfundibular neurons cannot be ruled out.

Original languageEnglish
Pages (from-to)358-362
Number of pages5
Issue number6
Publication statusPublished - 1981


  • Dopamine
  • Phosphatidylserine
  • Phospholipids
  • Prolactin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems
  • Neuroscience(all)


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