In vivo and in vitro response to a gelatin/α-tricalcium phosphate bone cement

B. Bracci, M. Fini, S. Panzavolta, P. Torricelli, A. Bigi

Research output: Contribution to journalArticle

Abstract

We recently developed a new biomimetic calcium phosphate bone cement enriched with gelatin (GEL-CP) which exhibits improved mechanical properties with respect to the control cement (C-CP) and a good response to osteoblast-like cells. In this work, we have extended the investigation to primary culture of osteoblasts derived from normal (N-OB) and osteopenic (O-OB) sheep bones cultured on samples of GEL-CP, and their behavior was compared to that of cells cultured on C-CP as control. Cell morphology, proliferation, and differentiation were evaluated at 3 and 7 days. Preliminary in vivo tests were carried out onto critical size defects in the radius diaphysisof rats.

Original languageEnglish
Pages (from-to)1001-1004
Number of pages4
JournalKey Engineering Materials
Volume361-363 II
Publication statusPublished - 2008

Keywords

  • Bone cement
  • Calcium phosphate
  • Gelatin
  • In vivo tests

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Ceramics and Composites

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