In vivo behaviour of neuraminidase-treated rabbit erythrocytes and reticulocytes

Carlo L. Balduini, Giovanni Ricevuti, Maria C. Sosso, Edoardo Ascari, Augusta Brovelli, Cesare Balduini

Research output: Contribution to journalArticlepeer-review

Abstract

51Cr rabbit erythrocytes were treated with different amounts of neuraminidase and reinjected into the animal. The survival curves after the removal of more than 50°/o membrane sialic acid show a characteristic behaviour: after a rapid decrease, blood radioactivity increases again reaching a maximum level 50-80 h after reinjection, then tends to decrease with a slope similar to that of control curves. Liver radioactivity determined before the rise of blood radioactivity is evidently higher than the value determined after radioactivity elevation. Similar results were obtained with phenylhydrazine-induced young erythrocytes.

Original languageEnglish
Pages (from-to)178-187
Number of pages10
JournalActa Haematologica
Volume57
Issue number3
DOIs
Publication statusPublished - 1977

Keywords

  • Erythrocyte life-span
  • Erythrocyte membrane
  • Neuraminidase
  • Rabbit erythrocytes
  • Sialic acid

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Hematology

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