In vivo characterization of healthy oral mucosa by reflectance confocal microscopy: A translational research for optical biopsy

Maria Contaldo, Marina Agozzino, Elvira Moscarella, Salvatore Esposito, Rosario Serpico, Marco Ardigò

Research output: Contribution to journalArticle

Abstract

Purpose: To characterize in vivo microscopic features of healthy oral mucosa by noninvasive, real-time reflectance confocal microscopy (RCM). Material and Methods: One hundred healthy mucosal sites (38 lips, 24 cheeks, 10 gingivae, and 28 tongues) from 50 randomly selected volunteers were imaged by a commercially available in vivo RCM (Vivascope3000, Lucid, Rochester, NY). Morphological results were described and correlated with conventional histology. Results: Specific microscopic parameters (cellular morphology, anatomical structures features, architectural patterns) were identified by RCM for each mucosal site. Conclusions: RCM features reproducibility in different mucosal sites and subjects, which suggests that RCM can be an adjunct tool for clinical management in stomatology.

Original languageEnglish
Pages (from-to)151-158
Number of pages8
JournalUltrastructural Pathology
Volume37
Issue number2
DOIs
Publication statusPublished - Apr 2013

Keywords

  • In vivo imaging
  • Oral mucosa
  • Reflectance confocal microscopy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Structural Biology

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