In vivo definition of parieto-motor connections involved in planning of grasping movements

Giacomo Koch, Mara Cercignani, Cristiano Pecchioli, Viviana Versace, Massimiliano Oliveri, Carlo Caltagirone, John Rothwell, Marco Bozzali

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

We combined bifocal transcranial magnetic stimulation (TMS) and diffusion tensor imaging (DTI) tractography to investigate in humans the contribution of connections originating from different parietal areas in planning of different reaching to grasp movements. TMS experiments revealed that in the left hemisphere functional connectivity between the primary motor cortex (M1) and a portion of the angular gyrus (AG) close to the caudal intraparietal sulcus was activated during early preparation of reaching and grasping movements only when the movement was made with a whole hand grasp (WHG) towards objects in contralateral space. In contrast, a different pathway, linking M1 with a part of the supramarginal gyrus (SMG) close to the anterior intraparietal sulcus, was sensitive only to the type of grasp required (precision grasping) but not to the position of the object in space. A triple coil experiment revealed that inactivation of the ventral premotor area (PMv) by continuous theta burst stimulation interfered with some of these interactions. Anatomical DTI tractography revealed that AG and SMG are strongly connected with PMv and with M1 by different bundles of the superior longitudinal fasciculus (SLF).These results demonstrate the existence of segregated parieto-premotor-motor pathways crucial for preparation of different grasping actions and indicate that these may process information relevant to both the position of the object and the hand shape required to use it.

Original languageEnglish
Pages (from-to)300-312
Number of pages13
JournalNeuroImage
Volume51
Issue number1
DOIs
Publication statusPublished - May 2010

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Parietal Lobe
Diffusion Tensor Imaging
Transcranial Magnetic Stimulation
Motor Cortex
Hand Strength
Hand
Efferent Pathways

Keywords

  • Connectivity
  • Movement planning
  • Superior longitudinal fasciculus
  • TMS
  • Tractography
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

In vivo definition of parieto-motor connections involved in planning of grasping movements. / Koch, Giacomo; Cercignani, Mara; Pecchioli, Cristiano; Versace, Viviana; Oliveri, Massimiliano; Caltagirone, Carlo; Rothwell, John; Bozzali, Marco.

In: NeuroImage, Vol. 51, No. 1, 05.2010, p. 300-312.

Research output: Contribution to journalArticle

Koch, Giacomo ; Cercignani, Mara ; Pecchioli, Cristiano ; Versace, Viviana ; Oliveri, Massimiliano ; Caltagirone, Carlo ; Rothwell, John ; Bozzali, Marco. / In vivo definition of parieto-motor connections involved in planning of grasping movements. In: NeuroImage. 2010 ; Vol. 51, No. 1. pp. 300-312.
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