Abstract
Objectives: To evaluate changes in T1 and T2* relaxometry of dentate nuclei (DN) with respect to the number of previous administrations of Gadolinium-based contrast agents (GBCA). Methods: In 74 relapsing-remitting multiple sclerosis (RR-MS) patients with variable disease duration (9.8±6.8 years) and severity (Expanded Disability Status Scale scores:3.1±0.9), the DN R1 (1/T1) and R2* (1/T2*) relaxation rates were measured using two unenhanced 3D Dual-Echo spoiled Gradient-Echo sequences with different flip angles. Correlations of the number of previous GBCA administrations with DN R1 and R2* relaxation rates were tested, including gender and age effect, in a multivariate regression analysis. Results: The DN R1 (normalized by brainstem) significantly correlated with the number of GBCA administrations (p
Original language | English |
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Pages (from-to) | 1-8 |
Number of pages | 8 |
Journal | European Radiology |
DOIs | |
Publication status | Accepted/In press - Feb 23 2016 |
Keywords
- Dentate nucleus
- Gadolinium
- MRI contrast media
- Multiple Sclerosis
- Relaxometry
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging