In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents

E. Tedeschi; Giuseppe Palma; Antonietta Canna; Sirio Cocozza; Carmela Russo; Pasquale Borrelli; Roberta Lanzillo; Valentina Angelini; Emanuela Postiglione; Vincenzo Brescia Morra; Marco Salvatore; Arturo Brunetti; M. Quarantelli

doi:10.1007/s00330-016-4245-2

In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents

E. Tedeschi, Giuseppe Palma, Antonietta Canna, Sirio Cocozza, Carmela Russo, Pasquale Borrelli, Roberta Lanzillo, Valentina Angelini, Emanuela Postiglione, Vincenzo Brescia Morra, Marco Salvatore, Arturo Brunetti, M. Quarantelli

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: To evaluate changes in T1 and T2* relaxometry of dentate nuclei (DN) with respect to the number of previous administrations of Gadolinium-based contrast agents (GBCA). Methods: In 74 relapsing-remitting multiple sclerosis (RR-MS) patients with variable disease duration (9.8±6.8 years) and severity (Expanded Disability Status Scale scores:3.1±0.9), the DN R1 (1/T1) and R2* (1/T2*) relaxation rates were measured using two unenhanced 3D Dual-Echo spoiled Gradient-Echo sequences with different flip angles. Correlations of the number of previous GBCA administrations with DN R1 and R2* relaxation rates were tested, including gender and age effect, in a multivariate regression analysis. Results: The DN R1 (normalized by brainstem) significantly correlated with the number of GBCA administrations (p

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	European Radiology
DOIs	https://doi.org/10.1007/s00330-016-4245-2
Publication status	Accepted/In press - Feb 23 2016

Keywords

Dentate nucleus
Gadolinium
MRI contrast media
Multiple Sclerosis
Relaxometry

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1007/s00330-016-4245-2

Cite this

Tedeschi, E., Palma, G., Canna, A., Cocozza, S., Russo, C., Borrelli, P., Lanzillo, R., Angelini, V., Postiglione, E., Morra, V. B., Salvatore, M., Brunetti, A., & Quarantelli, M. (Accepted/In press). In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents. European Radiology, 1-8. https://doi.org/10.1007/s00330-016-4245-2

In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents. / Tedeschi, E.; Palma, Giuseppe; Canna, Antonietta; Cocozza, Sirio; Russo, Carmela; Borrelli, Pasquale; Lanzillo, Roberta; Angelini, Valentina; Postiglione, Emanuela; Morra, Vincenzo Brescia; Salvatore, Marco; Brunetti, Arturo; Quarantelli, M.

In: European Radiology, 23.02.2016, p. 1-8.

Research output: Contribution to journal › Article › peer-review

Tedeschi, E. ; Palma, Giuseppe ; Canna, Antonietta ; Cocozza, Sirio ; Russo, Carmela ; Borrelli, Pasquale ; Lanzillo, Roberta ; Angelini, Valentina ; Postiglione, Emanuela ; Morra, Vincenzo Brescia ; Salvatore, Marco ; Brunetti, Arturo ; Quarantelli, M. / In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents. In: European Radiology. 2016 ; pp. 1-8.

@article{f45b369601174b4bbee7e69b92cb99ee,

title = "In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents",

abstract = "Objectives: To evaluate changes in T1 and T2* relaxometry of dentate nuclei (DN) with respect to the number of previous administrations of Gadolinium-based contrast agents (GBCA). Methods: In 74 relapsing-remitting multiple sclerosis (RR-MS) patients with variable disease duration (9.8±6.8 years) and severity (Expanded Disability Status Scale scores:3.1±0.9), the DN R1 (1/T1) and R2* (1/T2*) relaxation rates were measured using two unenhanced 3D Dual-Echo spoiled Gradient-Echo sequences with different flip angles. Correlations of the number of previous GBCA administrations with DN R1 and R2* relaxation rates were tested, including gender and age effect, in a multivariate regression analysis. Results: The DN R1 (normalized by brainstem) significantly correlated with the number of GBCA administrations (p",

keywords = "Dentate nucleus, Gadolinium, MRI contrast media, Multiple Sclerosis, Relaxometry",

author = "E. Tedeschi and Giuseppe Palma and Antonietta Canna and Sirio Cocozza and Carmela Russo and Pasquale Borrelli and Roberta Lanzillo and Valentina Angelini and Emanuela Postiglione and Morra, {Vincenzo Brescia} and Marco Salvatore and Arturo Brunetti and M. Quarantelli",

year = "2016",

month = feb,

day = "23",

doi = "10.1007/s00330-016-4245-2",

language = "English",

pages = "1--8",

journal = "European Radiology",

issn = "0938-7994",

publisher = "Springer Verlag",

}

TY - JOUR

T1 - In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents

AU - Tedeschi, E.

AU - Palma, Giuseppe

AU - Canna, Antonietta

AU - Cocozza, Sirio

AU - Russo, Carmela

AU - Borrelli, Pasquale

AU - Lanzillo, Roberta

AU - Angelini, Valentina

AU - Postiglione, Emanuela

AU - Morra, Vincenzo Brescia

AU - Salvatore, Marco

AU - Brunetti, Arturo

AU - Quarantelli, M.

PY - 2016/2/23

Y1 - 2016/2/23

N2 - Objectives: To evaluate changes in T1 and T2* relaxometry of dentate nuclei (DN) with respect to the number of previous administrations of Gadolinium-based contrast agents (GBCA). Methods: In 74 relapsing-remitting multiple sclerosis (RR-MS) patients with variable disease duration (9.8±6.8 years) and severity (Expanded Disability Status Scale scores:3.1±0.9), the DN R1 (1/T1) and R2* (1/T2*) relaxation rates were measured using two unenhanced 3D Dual-Echo spoiled Gradient-Echo sequences with different flip angles. Correlations of the number of previous GBCA administrations with DN R1 and R2* relaxation rates were tested, including gender and age effect, in a multivariate regression analysis. Results: The DN R1 (normalized by brainstem) significantly correlated with the number of GBCA administrations (p

AB - Objectives: To evaluate changes in T1 and T2* relaxometry of dentate nuclei (DN) with respect to the number of previous administrations of Gadolinium-based contrast agents (GBCA). Methods: In 74 relapsing-remitting multiple sclerosis (RR-MS) patients with variable disease duration (9.8±6.8 years) and severity (Expanded Disability Status Scale scores:3.1±0.9), the DN R1 (1/T1) and R2* (1/T2*) relaxation rates were measured using two unenhanced 3D Dual-Echo spoiled Gradient-Echo sequences with different flip angles. Correlations of the number of previous GBCA administrations with DN R1 and R2* relaxation rates were tested, including gender and age effect, in a multivariate regression analysis. Results: The DN R1 (normalized by brainstem) significantly correlated with the number of GBCA administrations (p

KW - Dentate nucleus

KW - Gadolinium

KW - MRI contrast media

KW - Multiple Sclerosis

KW - Relaxometry

UR - http://www.scopus.com/inward/record.url?scp=84959147891&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84959147891&partnerID=8YFLogxK

U2 - 10.1007/s00330-016-4245-2

DO - 10.1007/s00330-016-4245-2

M3 - Article

SP - 1

EP - 8

JO - European Radiology

JF - European Radiology

SN - 0938-7994

ER -

In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this