In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents

E. Tedeschi, Giuseppe Palma, Antonietta Canna, Sirio Cocozza, Carmela Russo, Pasquale Borrelli, Roberta Lanzillo, Valentina Angelini, Emanuela Postiglione, Vincenzo Brescia Morra, Marco Salvatore, Arturo Brunetti, M. Quarantelli

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To evaluate changes in T1 and T2* relaxometry of dentate nuclei (DN) with respect to the number of previous administrations of Gadolinium-based contrast agents (GBCA). Methods: In 74 relapsing-remitting multiple sclerosis (RR-MS) patients with variable disease duration (9.8±6.8 years) and severity (Expanded Disability Status Scale scores:3.1±0.9), the DN R1 (1/T1) and R2* (1/T2*) relaxation rates were measured using two unenhanced 3D Dual-Echo spoiled Gradient-Echo sequences with different flip angles. Correlations of the number of previous GBCA administrations with DN R1 and R2* relaxation rates were tested, including gender and age effect, in a multivariate regression analysis. Results: The DN R1 (normalized by brainstem) significantly correlated with the number of GBCA administrations (p

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalEuropean Radiology
DOIs
Publication statusAccepted/In press - Feb 23 2016

Keywords

  • Dentate nucleus
  • Gadolinium
  • MRI contrast media
  • Multiple Sclerosis
  • Relaxometry

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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