In vivo detection of iron and neuromelanin by transcranial sonography: A new approach for early detection of substantia nigra damage

Luigi Zecca, Daniela Berg, Thomas Arzberger, Petra Ruprecht, Wolf D. Rausch, Massimo Musicco, Davide Tampellini, Peter Riederer, Manfred Gerlach, Georg Becker

Research output: Contribution to journalArticle

Abstract

Early diagnosis of Parkinson's disease (PD) in nonsymptomatic patients is a key issue. An increased echogenicity of the substantia nigra (SN) was found previously in Parkinsonian patients and in a low percentage of healthy adults. These nonsymptomatic subjects also showed a reduced 18F-dopa uptake in striatum, suggesting a preclinical injury of the nigrostriatal system that could later proceed into PD. To investigate the ability of ultrasonography to detect markers of SN degeneration, such as iron deposition and neuromelanin depletion, we scanned postmortem brains from normal subjects at different ages by ultrasound and measured the echogenic area of the SN. The SN was then dissected and used for histological examinations and determination of iron, ferritin, and neuromelanin content. A significant positive correlation was found between the echogenic area of the SN and the concentration of iron, H- and L-ferritins. Multivariate analysis carried out considering the iron content showed a significant negative correlation between echogenicity and neuromelanin content of the SN. In PD, a typical loss of neuromelanin and increase of iron is observed in this brain area. The finding of a positive correlation between iron and ferritin levels and a negative correlation of neuromelanin content with the area of echogenicity at the SN could therefore provide an interesting basis for diagnosis and therapeutic follow-up studies in PD.

Original languageEnglish
Pages (from-to)1278-1285
Number of pages8
JournalMovement Disorders
Volume20
Issue number10
DOIs
Publication statusPublished - Oct 2005

Fingerprint

Substantia Nigra
Ultrasonography
Iron
Parkinson Disease
Apoferritins
Ferritins
Dihydroxyphenylalanine
Brain
neuromelanin
Early Diagnosis
Multivariate Analysis
Wounds and Injuries

Keywords

  • Ferritins
  • Neuromelanin
  • Parkinson's disease
  • Substantia nigra echogenicity
  • Transcranial ultrasound

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Zecca, L., Berg, D., Arzberger, T., Ruprecht, P., Rausch, W. D., Musicco, M., ... Becker, G. (2005). In vivo detection of iron and neuromelanin by transcranial sonography: A new approach for early detection of substantia nigra damage. Movement Disorders, 20(10), 1278-1285. https://doi.org/10.1002/mds.20550

In vivo detection of iron and neuromelanin by transcranial sonography : A new approach for early detection of substantia nigra damage. / Zecca, Luigi; Berg, Daniela; Arzberger, Thomas; Ruprecht, Petra; Rausch, Wolf D.; Musicco, Massimo; Tampellini, Davide; Riederer, Peter; Gerlach, Manfred; Becker, Georg.

In: Movement Disorders, Vol. 20, No. 10, 10.2005, p. 1278-1285.

Research output: Contribution to journalArticle

Zecca, L, Berg, D, Arzberger, T, Ruprecht, P, Rausch, WD, Musicco, M, Tampellini, D, Riederer, P, Gerlach, M & Becker, G 2005, 'In vivo detection of iron and neuromelanin by transcranial sonography: A new approach for early detection of substantia nigra damage', Movement Disorders, vol. 20, no. 10, pp. 1278-1285. https://doi.org/10.1002/mds.20550
Zecca, Luigi ; Berg, Daniela ; Arzberger, Thomas ; Ruprecht, Petra ; Rausch, Wolf D. ; Musicco, Massimo ; Tampellini, Davide ; Riederer, Peter ; Gerlach, Manfred ; Becker, Georg. / In vivo detection of iron and neuromelanin by transcranial sonography : A new approach for early detection of substantia nigra damage. In: Movement Disorders. 2005 ; Vol. 20, No. 10. pp. 1278-1285.
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