Abstract
Using positron emission tomography and [11C](R)-PK11195, a marker of "peripheral benzodiazepine sites" that is upregulated on activated microglia during progressive tissue pathology, we show increased binding of [11C](R)-PK11195 in frontotemporal lobar degeneration in the typically affected frontotemporal brain regions. This implies the presence of an active glial response reflecting progressive neuronal degeneration. It also suggests that increased [11C](R)-PK11195 binding, previously demonstrated for Alzheimer's disease, may occur independently from increased amyloid plaque formation, given that it is not a characteristic feature of frontotemporal lobar degeneration.
Original language | English |
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Pages (from-to) | 894-897 |
Number of pages | 4 |
Journal | Annals of Neurology |
Volume | 56 |
Issue number | 6 |
DOIs | |
Publication status | Published - Dec 2004 |
ASJC Scopus subject areas
- Neuroscience(all)