In vivo detection of microglial activation in frontotemporal dementia

Annachiara Cagnin, Martin Rossor, Elizabeth L. Sampson, Toby MacKinnon, Richard B. Banati

Research output: Contribution to journalArticlepeer-review

Abstract

Using positron emission tomography and [11C](R)-PK11195, a marker of "peripheral benzodiazepine sites" that is upregulated on activated microglia during progressive tissue pathology, we show increased binding of [11C](R)-PK11195 in frontotemporal lobar degeneration in the typically affected frontotemporal brain regions. This implies the presence of an active glial response reflecting progressive neuronal degeneration. It also suggests that increased [11C](R)-PK11195 binding, previously demonstrated for Alzheimer's disease, may occur independently from increased amyloid plaque formation, given that it is not a characteristic feature of frontotemporal lobar degeneration.

Original languageEnglish
Pages (from-to)894-897
Number of pages4
JournalAnnals of Neurology
Volume56
Issue number6
DOIs
Publication statusPublished - Dec 2004

ASJC Scopus subject areas

  • Neuroscience(all)

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