In vivo effect of copper status on cisplatin-induced nephrotoxicity

Ludmila V. Puchkova, Alexey N. Skvortsov, Paolo Rusconi, Ekaterina Yu Ilyechova, Massimo Broggini

Research output: Contribution to journalArticlepeer-review

Abstract

Cisplatin is a widely used antitumor agent; however, tumor resistance and severe side effects limit its use. It is well accepted that cisplatin toxicity can be modulated in vitro in cell cultures by copper salts. In the present work, mice with different blood serum copper status were treated with a single intraperitoneal cisplatin injection at a dose of 5 mg/kg, monitored for 3 days in metabolic cages and analyzed for renal function. Both copper-deficient and copper-overloaded mice displayed more severe early proteinuria and retarded platinum excretion than control mice. The effects of copper status on cisplatin-induced nephrotoxicity are discussed.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalBioMetals
DOIs
Publication statusAccepted/In press - Aug 1 2016

Keywords

  • Cisplatin
  • Murine model of copper status
  • Nephrotoxicity

ASJC Scopus subject areas

  • Biomaterials
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Metals and Alloys

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