In vivo effects of cyclosporin A on murine B-cells responding to type III pneumococcal polysaccharide

S. Sozzani, M. Sironi, M. Magistrelli, W. Luini, F. Spreafico, A. Vecchi

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of cyclosporin A (CSA) on the antibody response to pneumococcal polysaccharide type III (a T-independent class 2 antigen) was investigated in mice. A single oral CSA administration (50 mg/kg) was able to depress (40%) the primary antibody response evaluated as spleen plaque-forming cells. Repeated treatments (12-50 mg/kg × 5) resulted in a higher degree of inhibition (80%) of anti-SIII response. Both single and repeated CSA treatments were active only when administered concomitantly with or after immunization, whereas no effects were seen with drug pretreatment. Comparable inhibitions of anti-SIII response were observed in control and nude mice suggesting a direct effect of CSA on B-cells.

Original languageEnglish
Pages (from-to)359-364
Number of pages6
JournalInternational Journal of Immunopharmacology
Volume12
Issue number4
DOIs
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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