In vivo effects of maternal immunosupression during pregnancy on the immune function of newborn infants

Elisa Meregalli, Martina Biggioggero, Orietta Borghi, Pierluigi Meroni, Rolando Cimaz

Research output: Contribution to journalArticlepeer-review

Abstract

When used in pregnancy, immunosuppressants can cross the placental barrier and enter foetal circulation, possibly affecting the immune system of the foetus. This study evaluated the immune function in eight children born by mothers with connective tissue diseases who received immunosuppressants (cyclosporine A or dexamethasone) during pregnancy and in six babies from mothers with similar diseases, but who did not receive any treatment. Judging by the cytokine production of interleukin-2 and interferon-γ in peripheral blood mononuclear cells stimulated by phorbol-myristate-acetate (PMA) and ionomycin, immunosuppressive drugs given for rheumatic disorders during pregnancy do not induce significant immunosuppression in babies.

Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalArhiv za Higijenu Rada i Toksikologiju
Volume56
Issue number2
Publication statusPublished - Jun 2005

Keywords

  • Cyclosporine A
  • Dexamethasone
  • Immune function
  • Immunosuppressants
  • Newborns
  • Vaccination

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Toxicology

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