In Vivo Effects of Thymustimulin on Hematopoiesis of Mice Treated with Cyclophosphamide

Enrico Balleari, Giulio Massa, Cristina Musselii, Silvana Timitilli, Alessandra Battaglia, Riccardo Ghio

Research output: Contribution to journalArticle

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Abstract

This study reports on the in vivo effects of thymustimulin (TST), a thymic extract, on the hematopoiesis of mice treated with cyclophosphamide (CTX). Peripheral blood counts and both bone marrow pluripotent (spleen colonyforming units, CFU-S) and committed (granulocyte-macrophage colony-forming units, CFU-GM; erythroid burst-forming units, BFU-E) hematopoietic progenitor cells were assayed by in vitro methods. Administration of CTX alone was associated with severe hemotoxicity, which was followed by a gradual recovery of hematopoiesis. Hematotoxic effect of CTX was less pronounced when TST was administered in association with CTX. All the studied parameters were higher in TST + CTX-treated animals than those in CTX-treated animals, especially after Day 5 from the beginning of treatment for blood leukocytes, bone marrow cell counts, and packed red cell volume, and at Day 10 or 15 for CFU-S, CFU-GM, and BFU-E. These findings suggest that, in this experimental model, the simultaneous administration of TST reduces the myelosuppressive activity of CTX in vivo.

Original languageEnglish
Pages (from-to)363-367
Number of pages5
JournalClinical Immunology and Immunopathology
Volume68
Issue number3
DOIs
Publication statusPublished - Sep 1993

Fingerprint

Hematopoiesis
Cyclophosphamide
Granulocyte-Macrophage Progenitor Cells
Erythroid Precursor Cells
Hematopoietic Stem Cells
Hematocrit
Bone Marrow Cells
Leukocytes
Theoretical Models
Spleen
Cell Count
Bone Marrow
thymostimulin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Immunology and Allergy
  • Immunology

Cite this

In Vivo Effects of Thymustimulin on Hematopoiesis of Mice Treated with Cyclophosphamide. / Balleari, Enrico; Massa, Giulio; Musselii, Cristina; Timitilli, Silvana; Battaglia, Alessandra; Ghio, Riccardo.

In: Clinical Immunology and Immunopathology, Vol. 68, No. 3, 09.1993, p. 363-367.

Research output: Contribution to journalArticle

Balleari, Enrico ; Massa, Giulio ; Musselii, Cristina ; Timitilli, Silvana ; Battaglia, Alessandra ; Ghio, Riccardo. / In Vivo Effects of Thymustimulin on Hematopoiesis of Mice Treated with Cyclophosphamide. In: Clinical Immunology and Immunopathology. 1993 ; Vol. 68, No. 3. pp. 363-367.
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