In vivo emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae and Escherichia coli

Teresa Spanu, Giulia De Angelis, Michela Cipriani, Barbara Pedruzzi, Tiziana D'Inzeo, Maria Adriana Cataldo, Gabriele Sganga, Evelina Tacconelli

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Although resistance to tigecycline has been reported in surveillance studies, very few reports have described the emergence of resistance in vivo. We report two cases of patients with infections due to SHV-12-producing Klebsiella pneumoniae and K. pneumoniae carbapenemase-3 (KPC-3)-producing Escherichia coli, which developed tigecycline resistance in vivo after treatment. The reported limited experience underlines the risk of occurrence of a tigecycline MIC increase under treatment pressure.

Original languageEnglish
Pages (from-to)4516-4518
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume56
Issue number8
DOIs
Publication statusPublished - Aug 2012

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Klebsiella pneumoniae
Multiple Drug Resistance
Escherichia coli
Pressure
Therapeutics
Infection
tigecycline

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

In vivo emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae and Escherichia coli. / Spanu, Teresa; De Angelis, Giulia; Cipriani, Michela; Pedruzzi, Barbara; D'Inzeo, Tiziana; Cataldo, Maria Adriana; Sganga, Gabriele; Tacconelli, Evelina.

In: Antimicrobial Agents and Chemotherapy, Vol. 56, No. 8, 08.2012, p. 4516-4518.

Research output: Contribution to journalArticle

Spanu, T, De Angelis, G, Cipriani, M, Pedruzzi, B, D'Inzeo, T, Cataldo, MA, Sganga, G & Tacconelli, E 2012, 'In vivo emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae and Escherichia coli', Antimicrobial Agents and Chemotherapy, vol. 56, no. 8, pp. 4516-4518. https://doi.org/10.1128/AAC.00234-12
Spanu, Teresa ; De Angelis, Giulia ; Cipriani, Michela ; Pedruzzi, Barbara ; D'Inzeo, Tiziana ; Cataldo, Maria Adriana ; Sganga, Gabriele ; Tacconelli, Evelina. / In vivo emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae and Escherichia coli. In: Antimicrobial Agents and Chemotherapy. 2012 ; Vol. 56, No. 8. pp. 4516-4518.
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