In vivo estimation of the flow-driven adiabatic inversion efficiency for continuous arterial spin labeling: A method using phase contrast magnetic resonance angiography

Ruth L. O'Gorman, Paul E. Summers, Fernando O. Zelaya, Steven C R Williams, David C. Alsop, David J. Lythgoe

Research output: Contribution to journalArticlepeer-review

Abstract

The accurate quantification of perfusion with arterial spin labeling (ASL) requires consideration of a number of factors, including the efficiency of the inversion and control pulses used for spin labeling. In this study the effects of spin velocity on continuous ASL efficiency when using the amplitude modulated control strategy were investigated using simulations of the Bloch equations. The inversion efficiency was determined in vivo by combining the simulations with phase-contrast velocity mapping data acquired at the level of the tagging plane. Using this novel method, an average inversion efficiency of 69% was calculated for a group of 28 subjects, in good agreement with experimental data reported previously. There was, however, a large range in inversion efficiency measured across the subject group (50-76%), indicating that the velocity dependence of the amplitude modulated control efficiency may introduce additional variability into the perfusion calculations if not properly taken into account.

Original languageEnglish
Pages (from-to)1291-1297
Number of pages7
JournalMagnetic Resonance in Medicine
Volume55
Issue number6
DOIs
Publication statusPublished - Jun 2006

Keywords

  • Adiabatic inversion efficiency
  • Arterial spin labeling
  • Magnetic resonance angiography
  • Perfusion
  • Velocity mapping

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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