TY - JOUR
T1 - In vivo evaluation of melanoma thickness by multispectral imaging and an artificial neural network. A retrospective study on 250 cases of cutaneous melanoma
AU - Marchesini, Renato
AU - Bono, Aldo
AU - Tomatis, Stefano
AU - Bartoli, Cesare
AU - Colombo, Ambrogio
AU - Lualdi, Manuela
AU - Carrara, Mauro
PY - 2007/3
Y1 - 2007/3
N2 - Aims and background: Noninvasive diagnostic methods such as dermoscopy, sonography, palpation or combined approaches have been developed in an attempt to preoperatively estimate melanoma thickness. However, the clinical presentation is often complex and the evaluation subjective. Multispectral image analysis of melanomas allows selection of features related to the content and distribution of absorbers, mainly melanin and hemoglobin, present within the lesion. Hence, it is reasonable to assume that the same features might be useful to predict melanoma thickness. Methods: A multispectral image system was used to analyze in vivo 1939 pigmented skin lesions. The lesion selection was based on clinical and/or dermoscopic features that supported a suspicion for melanoma. All the lesions were then subjected to surgery for the histopathological diagnosis, and 250 were melanomas. From the multispectral images of the melanomas, we selected 12 features, seven of which were used to train and test an artificial neural network on 155 and 95 melanomas, respectively. Results: Sensitivity (i.e., melanoma ≥0.75 mm thick correctly classified) and specificity (i.e., melanoma
AB - Aims and background: Noninvasive diagnostic methods such as dermoscopy, sonography, palpation or combined approaches have been developed in an attempt to preoperatively estimate melanoma thickness. However, the clinical presentation is often complex and the evaluation subjective. Multispectral image analysis of melanomas allows selection of features related to the content and distribution of absorbers, mainly melanin and hemoglobin, present within the lesion. Hence, it is reasonable to assume that the same features might be useful to predict melanoma thickness. Methods: A multispectral image system was used to analyze in vivo 1939 pigmented skin lesions. The lesion selection was based on clinical and/or dermoscopic features that supported a suspicion for melanoma. All the lesions were then subjected to surgery for the histopathological diagnosis, and 250 were melanomas. From the multispectral images of the melanomas, we selected 12 features, seven of which were used to train and test an artificial neural network on 155 and 95 melanomas, respectively. Results: Sensitivity (i.e., melanoma ≥0.75 mm thick correctly classified) and specificity (i.e., melanoma
KW - Artificial neural network
KW - Breslow thickness
KW - Image analysis
KW - Melanoma
KW - Spectrophotometry
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M3 - Article
C2 - 17557564
AN - SCOPUS:34249901293
VL - 93
SP - 170
EP - 177
JO - Tumori
JF - Tumori
SN - 0300-8916
IS - 2
ER -