In vivo evaluation of the effect of intramedullary nail microtopography on the development of local infection in rabbits

Thomas Fintan Moriarty, Davide Campoccia, Stephanie K. Nees, Ludovic P. Boure, Robert G. Richards

Research output: Contribution to journalArticlepeer-review


Background and Aim: Fractures of the tibia and femoral diaphysis are commonly repaired by intramedullary (IM) nails, which are currently composed of either electropolished stainless steel (EPSS) or standard, non-polished titanium-aluminum-niobium (TAN). Once the fracture has fully healed, removal of IM nails is common, but the strong adhesion of bone to standard TAN complicates removal. Polishing the surface of TAN IM nails has been shown to reduce bony adhesion and ease implant removal without compromising fixation. Polished TAN nails are, therefore, expected to have significant clinical benefit in situations where the device is to be removed. The aim of the present study was to determine the effect of polishing TAN IM nails on susceptibility to infection in an animal model. Materials and Methods: Solid IM nails (Synthes, Betlach, Switzerland) composed of standard TAN were compared with polished equivalents and also to clinically available EPSS nails. The surface chemical and topographical properties of the materials were assessed by X-ray photon spectroscopy (XPS), white light profilometry, and scanning electron microscopy (SEM). An in vivo infection study was performed using a clinical isolate of Staphylococcus aureus that was characterized with respect to various virulence factors. Results: Polishing TAN IM nails caused no significant change to the chemistry of the nails, but the topography of the polished TAN nails was significantly smoother than standard TAN nails. In the infection study, the rank order based on descending infectious dose 50 (ID50) was: standard TAN, polished TAN, and finally EPSS. The ID50 values did not differ greatly between any of the groups. Conclusions: Polishing the surface TAN IM nails was not found to influence the susceptibility to infection in our animal model.

Original languageEnglish
Pages (from-to)667-675
Number of pages9
JournalInternational Journal of Artificial Organs
Issue number9
Publication statusPublished - Sep 2010


  • Infection
  • Intramedullary nail
  • Polishing
  • Staphylococcus aureus
  • Surface

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Bioengineering
  • Medicine (miscellaneous)


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