In vivo evaluation of type 2 transglutaminase contribution to the metastasis formation in melanoma

G. Di Giacomo, A. Lentini, S. Beninati, M. Piacentini, C. Rodolfo

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

One of the most relevant problems in tumour treatment resides on the ability of the tumour to form metastasis and disseminate among the organism. The formation of metastases is a complex process, which requires the action of various effectors, not yet completely identified. The analysis of various types of tumours revealed a complex picture about the relationship between type 2 transglutaminase (TG2) expression and outcome and/or metastatic potential of the tumour itself. In some tumours, the transition to a highly invasive state is paralleled by an up-regulation of TG2 expression and/or activity while in some other a down-regulation has been reported. In addition, host tissues seem to react to tumour invasion by up-regulating TG2 expression. In order to analyse whether TG2 might be involved in the metastatic process in melanoma, we studied the metastases formation and development by means of the B16-F10 murine melanoma cell line and with TG2-/- mice as experimental model. Our results indicate that TG2 absence in the host is a favouring condition for the formation and development of the metastasis, while the presence of TG2 in the tumour's cell might be requested for the development of the metastasis.

Original languageEnglish
Pages (from-to)717-724
Number of pages8
JournalAmino Acids
Volume36
Issue number4
DOIs
Publication statusPublished - Apr 2009

Fingerprint

Tumors
Melanoma
Neoplasm Metastasis
Neoplasms
Cells
transglutaminase 2
Theoretical Models
Up-Regulation
Down-Regulation
Tissue
Cell Line

Keywords

  • B16-F10
  • Melanoma
  • Metastasis
  • Transglutaminase 2

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

In vivo evaluation of type 2 transglutaminase contribution to the metastasis formation in melanoma. / Di Giacomo, G.; Lentini, A.; Beninati, S.; Piacentini, M.; Rodolfo, C.

In: Amino Acids, Vol. 36, No. 4, 04.2009, p. 717-724.

Research output: Contribution to journalArticle

Di Giacomo, G. ; Lentini, A. ; Beninati, S. ; Piacentini, M. ; Rodolfo, C. / In vivo evaluation of type 2 transglutaminase contribution to the metastasis formation in melanoma. In: Amino Acids. 2009 ; Vol. 36, No. 4. pp. 717-724.
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