Abstract
One of the most relevant problems in tumour treatment resides on the ability of the tumour to form metastasis and disseminate among the organism. The formation of metastases is a complex process, which requires the action of various effectors, not yet completely identified. The analysis of various types of tumours revealed a complex picture about the relationship between type 2 transglutaminase (TG2) expression and outcome and/or metastatic potential of the tumour itself. In some tumours, the transition to a highly invasive state is paralleled by an up-regulation of TG2 expression and/or activity while in some other a down-regulation has been reported. In addition, host tissues seem to react to tumour invasion by up-regulating TG2 expression. In order to analyse whether TG2 might be involved in the metastatic process in melanoma, we studied the metastases formation and development by means of the B16-F10 murine melanoma cell line and with TG2-/- mice as experimental model. Our results indicate that TG2 absence in the host is a favouring condition for the formation and development of the metastasis, while the presence of TG2 in the tumour's cell might be requested for the development of the metastasis.
| Original language | English |
|---|---|
| Pages (from-to) | 717-724 |
| Number of pages | 8 |
| Journal | Amino Acids |
| Volume | 36 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2009 |
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Keywords
- B16-F10
- Melanoma
- Metastasis
- Transglutaminase 2
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Organic Chemistry
Cite this
In vivo evaluation of type 2 transglutaminase contribution to the metastasis formation in melanoma. / Di Giacomo, G.; Lentini, A.; Beninati, S.; Piacentini, M.; Rodolfo, C.
In: Amino Acids, Vol. 36, No. 4, 04.2009, p. 717-724.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vivo evaluation of type 2 transglutaminase contribution to the metastasis formation in melanoma
AU - Di Giacomo, G.
AU - Lentini, A.
AU - Beninati, S.
AU - Piacentini, M.
AU - Rodolfo, C.
PY - 2009/4
Y1 - 2009/4
N2 - One of the most relevant problems in tumour treatment resides on the ability of the tumour to form metastasis and disseminate among the organism. The formation of metastases is a complex process, which requires the action of various effectors, not yet completely identified. The analysis of various types of tumours revealed a complex picture about the relationship between type 2 transglutaminase (TG2) expression and outcome and/or metastatic potential of the tumour itself. In some tumours, the transition to a highly invasive state is paralleled by an up-regulation of TG2 expression and/or activity while in some other a down-regulation has been reported. In addition, host tissues seem to react to tumour invasion by up-regulating TG2 expression. In order to analyse whether TG2 might be involved in the metastatic process in melanoma, we studied the metastases formation and development by means of the B16-F10 murine melanoma cell line and with TG2-/- mice as experimental model. Our results indicate that TG2 absence in the host is a favouring condition for the formation and development of the metastasis, while the presence of TG2 in the tumour's cell might be requested for the development of the metastasis.
AB - One of the most relevant problems in tumour treatment resides on the ability of the tumour to form metastasis and disseminate among the organism. The formation of metastases is a complex process, which requires the action of various effectors, not yet completely identified. The analysis of various types of tumours revealed a complex picture about the relationship between type 2 transglutaminase (TG2) expression and outcome and/or metastatic potential of the tumour itself. In some tumours, the transition to a highly invasive state is paralleled by an up-regulation of TG2 expression and/or activity while in some other a down-regulation has been reported. In addition, host tissues seem to react to tumour invasion by up-regulating TG2 expression. In order to analyse whether TG2 might be involved in the metastatic process in melanoma, we studied the metastases formation and development by means of the B16-F10 murine melanoma cell line and with TG2-/- mice as experimental model. Our results indicate that TG2 absence in the host is a favouring condition for the formation and development of the metastasis, while the presence of TG2 in the tumour's cell might be requested for the development of the metastasis.
KW - B16-F10
KW - Melanoma
KW - Metastasis
KW - Transglutaminase 2
UR - http://www.scopus.com/inward/record.url?scp=62949108431&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=62949108431&partnerID=8YFLogxK
U2 - 10.1007/s00726-008-0119-5
DO - 10.1007/s00726-008-0119-5
M3 - Article
C2 - 18594948
AN - SCOPUS:62949108431
VL - 36
SP - 717
EP - 724
JO - Amino Acids
JF - Amino Acids
SN - 0939-4451
IS - 4
ER -