Abstract
A dysfunction of the orexin (hypocretin) system in the hypothalamus has recently been linked to the pathogenesis of narcolepsy. The authors used in vivo proton MR spectroscopy to assess the N-acetylaspartate (NAA) content in the hypothalamus of narcoleptic patients. Hypothalamic NAA/creatine-phosphocreatine was reduced in narcoleptic patients compared with control subjects (p <0.01). Hypothalamic neuronal loss/damage is a central pathogenetic feature in narcolepsy.
Original language | English |
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Pages (from-to) | 1513-1515 |
Number of pages | 3 |
Journal | Neurology |
Volume | 63 |
Issue number | 8 |
Publication status | Published - Oct 26 2004 |
ASJC Scopus subject areas
- Neuroscience(all)