In vivo evidence of neuronal loss in the hypothalamus of narcoleptic patients

Raffaele Lodi; C. Tonon; L. Vignatelli; S. Iotti; P. Montagna; B. Barbiroli; G. Plazzi

In vivo evidence of neuronal loss in the hypothalamus of narcoleptic patients

Raffaele Lodi, C. Tonon, L. Vignatelli, S. Iotti, P. Montagna, B. Barbiroli, G. Plazzi

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

A dysfunction of the orexin (hypocretin) system in the hypothalamus has recently been linked to the pathogenesis of narcolepsy. The authors used in vivo proton MR spectroscopy to assess the N-acetylaspartate (NAA) content in the hypothalamus of narcoleptic patients. Hypothalamic NAA/creatine-phosphocreatine was reduced in narcoleptic patients compared with control subjects (p <0.01). Hypothalamic neuronal loss/damage is a central pathogenetic feature in narcolepsy.

Original language	English
Pages (from-to)	1513-1515
Number of pages	3
Journal	Neurology
Volume	63
Issue number	8
Publication status	Published - Oct 26 2004

ASJC Scopus subject areas

Neuroscience(all)

Cite this

@article{0a5e7d9eca054bbda37b49c3a41dda99,

title = "In vivo evidence of neuronal loss in the hypothalamus of narcoleptic patients",

abstract = "A dysfunction of the orexin (hypocretin) system in the hypothalamus has recently been linked to the pathogenesis of narcolepsy. The authors used in vivo proton MR spectroscopy to assess the N-acetylaspartate (NAA) content in the hypothalamus of narcoleptic patients. Hypothalamic NAA/creatine-phosphocreatine was reduced in narcoleptic patients compared with control subjects (p <0.01). Hypothalamic neuronal loss/damage is a central pathogenetic feature in narcolepsy.",

author = "Raffaele Lodi and C. Tonon and L. Vignatelli and S. Iotti and P. Montagna and B. Barbiroli and G. Plazzi",

year = "2004",

month = oct,

day = "26",

language = "English",

volume = "63",

pages = "1513--1515",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

number = "8",

}

TY - JOUR

T1 - In vivo evidence of neuronal loss in the hypothalamus of narcoleptic patients

AU - Lodi, Raffaele

AU - Tonon, C.

AU - Vignatelli, L.

AU - Iotti, S.

AU - Montagna, P.

AU - Barbiroli, B.

AU - Plazzi, G.

PY - 2004/10/26

Y1 - 2004/10/26

N2 - A dysfunction of the orexin (hypocretin) system in the hypothalamus has recently been linked to the pathogenesis of narcolepsy. The authors used in vivo proton MR spectroscopy to assess the N-acetylaspartate (NAA) content in the hypothalamus of narcoleptic patients. Hypothalamic NAA/creatine-phosphocreatine was reduced in narcoleptic patients compared with control subjects (p <0.01). Hypothalamic neuronal loss/damage is a central pathogenetic feature in narcolepsy.

AB - A dysfunction of the orexin (hypocretin) system in the hypothalamus has recently been linked to the pathogenesis of narcolepsy. The authors used in vivo proton MR spectroscopy to assess the N-acetylaspartate (NAA) content in the hypothalamus of narcoleptic patients. Hypothalamic NAA/creatine-phosphocreatine was reduced in narcoleptic patients compared with control subjects (p <0.01). Hypothalamic neuronal loss/damage is a central pathogenetic feature in narcolepsy.

UR - http://www.scopus.com/inward/record.url?scp=7044221981&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=7044221981&partnerID=8YFLogxK

M3 - Article

C2 - 15505179

AN - SCOPUS:7044221981

VL - 63

SP - 1513

EP - 1515

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 8

ER -

In vivo evidence of neuronal loss in the hypothalamus of narcoleptic patients

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this