In vivo evidence of neuronal loss in the hypothalamus of narcoleptic patients

Raffaele Lodi, C. Tonon, L. Vignatelli, S. Iotti, P. Montagna, B. Barbiroli, G. Plazzi

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

A dysfunction of the orexin (hypocretin) system in the hypothalamus has recently been linked to the pathogenesis of narcolepsy. The authors used in vivo proton MR spectroscopy to assess the N-acetylaspartate (NAA) content in the hypothalamus of narcoleptic patients. Hypothalamic NAA/creatine-phosphocreatine was reduced in narcoleptic patients compared with control subjects (p <0.01). Hypothalamic neuronal loss/damage is a central pathogenetic feature in narcolepsy.

Original languageEnglish
Pages (from-to)1513-1515
Number of pages3
JournalNeurology
Volume63
Issue number8
Publication statusPublished - Oct 26 2004

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Narcolepsy
Hypothalamus
Phosphocreatine
Creatine
Protons
Magnetic Resonance Spectroscopy
N-acetylaspartate
Orexins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lodi, R., Tonon, C., Vignatelli, L., Iotti, S., Montagna, P., Barbiroli, B., & Plazzi, G. (2004). In vivo evidence of neuronal loss in the hypothalamus of narcoleptic patients. Neurology, 63(8), 1513-1515.

In vivo evidence of neuronal loss in the hypothalamus of narcoleptic patients. / Lodi, Raffaele; Tonon, C.; Vignatelli, L.; Iotti, S.; Montagna, P.; Barbiroli, B.; Plazzi, G.

In: Neurology, Vol. 63, No. 8, 26.10.2004, p. 1513-1515.

Research output: Contribution to journalArticle

Lodi, R, Tonon, C, Vignatelli, L, Iotti, S, Montagna, P, Barbiroli, B & Plazzi, G 2004, 'In vivo evidence of neuronal loss in the hypothalamus of narcoleptic patients', Neurology, vol. 63, no. 8, pp. 1513-1515.
Lodi R, Tonon C, Vignatelli L, Iotti S, Montagna P, Barbiroli B et al. In vivo evidence of neuronal loss in the hypothalamus of narcoleptic patients. Neurology. 2004 Oct 26;63(8):1513-1515.
Lodi, Raffaele ; Tonon, C. ; Vignatelli, L. ; Iotti, S. ; Montagna, P. ; Barbiroli, B. ; Plazzi, G. / In vivo evidence of neuronal loss in the hypothalamus of narcoleptic patients. In: Neurology. 2004 ; Vol. 63, No. 8. pp. 1513-1515.
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