Abstract
A dysfunction of the orexin (hypocretin) system in the hypothalamus has recently been linked to the pathogenesis of narcolepsy. The authors used in vivo proton MR spectroscopy to assess the N-acetylaspartate (NAA) content in the hypothalamus of narcoleptic patients. Hypothalamic NAA/creatine-phosphocreatine was reduced in narcoleptic patients compared with control subjects (p <0.01). Hypothalamic neuronal loss/damage is a central pathogenetic feature in narcolepsy.
| Original language | English |
|---|---|
| Pages (from-to) | 1513-1515 |
| Number of pages | 3 |
| Journal | Neurology |
| Volume | 63 |
| Issue number | 8 |
| Publication status | Published - Oct 26 2004 |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
In vivo evidence of neuronal loss in the hypothalamus of narcoleptic patients. / Lodi, Raffaele; Tonon, C.; Vignatelli, L.; Iotti, S.; Montagna, P.; Barbiroli, B.; Plazzi, G.
In: Neurology, Vol. 63, No. 8, 26.10.2004, p. 1513-1515.Research output: Contribution to journal › Article
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TY - JOUR
T1 - In vivo evidence of neuronal loss in the hypothalamus of narcoleptic patients
AU - Lodi, Raffaele
AU - Tonon, C.
AU - Vignatelli, L.
AU - Iotti, S.
AU - Montagna, P.
AU - Barbiroli, B.
AU - Plazzi, G.
PY - 2004/10/26
Y1 - 2004/10/26
N2 - A dysfunction of the orexin (hypocretin) system in the hypothalamus has recently been linked to the pathogenesis of narcolepsy. The authors used in vivo proton MR spectroscopy to assess the N-acetylaspartate (NAA) content in the hypothalamus of narcoleptic patients. Hypothalamic NAA/creatine-phosphocreatine was reduced in narcoleptic patients compared with control subjects (p <0.01). Hypothalamic neuronal loss/damage is a central pathogenetic feature in narcolepsy.
AB - A dysfunction of the orexin (hypocretin) system in the hypothalamus has recently been linked to the pathogenesis of narcolepsy. The authors used in vivo proton MR spectroscopy to assess the N-acetylaspartate (NAA) content in the hypothalamus of narcoleptic patients. Hypothalamic NAA/creatine-phosphocreatine was reduced in narcoleptic patients compared with control subjects (p <0.01). Hypothalamic neuronal loss/damage is a central pathogenetic feature in narcolepsy.
UR - http://www.scopus.com/inward/record.url?scp=7044221981&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=7044221981&partnerID=8YFLogxK
M3 - Article
C2 - 15505179
AN - SCOPUS:7044221981
VL - 63
SP - 1513
EP - 1515
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 8
ER -