In vivo evidence of neuronal loss in the hypothalamus of narcoleptic patients

Raffaele Lodi, C. Tonon, L. Vignatelli, S. Iotti, P. Montagna, B. Barbiroli, G. Plazzi

Research output: Contribution to journalArticlepeer-review

Abstract

A dysfunction of the orexin (hypocretin) system in the hypothalamus has recently been linked to the pathogenesis of narcolepsy. The authors used in vivo proton MR spectroscopy to assess the N-acetylaspartate (NAA) content in the hypothalamus of narcoleptic patients. Hypothalamic NAA/creatine-phosphocreatine was reduced in narcoleptic patients compared with control subjects (p <0.01). Hypothalamic neuronal loss/damage is a central pathogenetic feature in narcolepsy.

Original languageEnglish
Pages (from-to)1513-1515
Number of pages3
JournalNeurology
Volume63
Issue number8
Publication statusPublished - Oct 26 2004

ASJC Scopus subject areas

  • Neuroscience(all)

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