IN VIVO EXPERIMENTAL EVALUATION OF BIOPROSTHETIC CARDIAC VALVES.

Michael Jones; Eloisa Arbustini; Elling E. Eidbo; Victor J. Ferrans

IN VIVO EXPERIMENTAL EVALUATION OF BIOPROSTHETIC CARDIAC VALVES.

Michael Jones, Eloisa Arbustini, Elling E. Eidbo, Victor J. Ferrans

IRCCS Fondazione Policlinico San Matteo

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

During the past 4 years an animal model system has been developed in juvenile (10-15) week old sheep which permits early and late studies of host-prosthesis interactions. Over 300 porcine aortic valves (PAV) and bovine pericardial valves (BPV) have been implanted in the tricuspid (TVR) or mitral (MVR) positions. Long-term survival (30 days-1 year) in the last 200 animals has been greater than 90%. In analyzing the results obtained with valve implantations in this model system, emphasis has been given to: 1) early and late hemodynamic investigations of valve function; 2) pathologic alterations, including localization of calcific deposits; 3) quantitative analysis of valve calcification; 4) evaluations of treatment processes to decrease valve calcification; and 5) use of intracardiac Doppler/2-D echocardiography to study valve function.

Original language	English
Title of host publication	Unknown Host Publication Title
Publisher	Assoc for the Advancement of Medical Instrumentation
Pages	40
Number of pages	1
ISBN (Print)	0910275343
Publication status	Published - 1984

ASJC Scopus subject areas

Engineering(all)

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Cite this

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title = "IN VIVO EXPERIMENTAL EVALUATION OF BIOPROSTHETIC CARDIAC VALVES.",

abstract = "During the past 4 years an animal model system has been developed in juvenile (10-15) week old sheep which permits early and late studies of host-prosthesis interactions. Over 300 porcine aortic valves (PAV) and bovine pericardial valves (BPV) have been implanted in the tricuspid (TVR) or mitral (MVR) positions. Long-term survival (30 days-1 year) in the last 200 animals has been greater than 90%. In analyzing the results obtained with valve implantations in this model system, emphasis has been given to: 1) early and late hemodynamic investigations of valve function; 2) pathologic alterations, including localization of calcific deposits; 3) quantitative analysis of valve calcification; 4) evaluations of treatment processes to decrease valve calcification; and 5) use of intracardiac Doppler/2-D echocardiography to study valve function.",

author = "Michael Jones and Eloisa Arbustini and Eidbo, {Elling E.} and Ferrans, {Victor J.}",

year = "1984",

language = "English",

isbn = "0910275343",

pages = "40",

booktitle = "Unknown Host Publication Title",

publisher = "Assoc for the Advancement of Medical Instrumentation",

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T1 - IN VIVO EXPERIMENTAL EVALUATION OF BIOPROSTHETIC CARDIAC VALVES.

AU - Jones, Michael

AU - Arbustini, Eloisa

AU - Eidbo, Elling E.

AU - Ferrans, Victor J.

PY - 1984

Y1 - 1984

N2 - During the past 4 years an animal model system has been developed in juvenile (10-15) week old sheep which permits early and late studies of host-prosthesis interactions. Over 300 porcine aortic valves (PAV) and bovine pericardial valves (BPV) have been implanted in the tricuspid (TVR) or mitral (MVR) positions. Long-term survival (30 days-1 year) in the last 200 animals has been greater than 90%. In analyzing the results obtained with valve implantations in this model system, emphasis has been given to: 1) early and late hemodynamic investigations of valve function; 2) pathologic alterations, including localization of calcific deposits; 3) quantitative analysis of valve calcification; 4) evaluations of treatment processes to decrease valve calcification; and 5) use of intracardiac Doppler/2-D echocardiography to study valve function.

AB - During the past 4 years an animal model system has been developed in juvenile (10-15) week old sheep which permits early and late studies of host-prosthesis interactions. Over 300 porcine aortic valves (PAV) and bovine pericardial valves (BPV) have been implanted in the tricuspid (TVR) or mitral (MVR) positions. Long-term survival (30 days-1 year) in the last 200 animals has been greater than 90%. In analyzing the results obtained with valve implantations in this model system, emphasis has been given to: 1) early and late hemodynamic investigations of valve function; 2) pathologic alterations, including localization of calcific deposits; 3) quantitative analysis of valve calcification; 4) evaluations of treatment processes to decrease valve calcification; and 5) use of intracardiac Doppler/2-D echocardiography to study valve function.

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