IN VIVO EXPERIMENTAL EVALUATION OF BIOPROSTHETIC CARDIAC VALVES.

Michael Jones, Eloisa Arbustini, Elling E. Eidbo, Victor J. Ferrans

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

During the past 4 years an animal model system has been developed in juvenile (10-15) week old sheep which permits early and late studies of host-prosthesis interactions. Over 300 porcine aortic valves (PAV) and bovine pericardial valves (BPV) have been implanted in the tricuspid (TVR) or mitral (MVR) positions. Long-term survival (30 days-1 year) in the last 200 animals has been greater than 90%. In analyzing the results obtained with valve implantations in this model system, emphasis has been given to: 1) early and late hemodynamic investigations of valve function; 2) pathologic alterations, including localization of calcific deposits; 3) quantitative analysis of valve calcification; 4) evaluations of treatment processes to decrease valve calcification; and 5) use of intracardiac Doppler/2-D echocardiography to study valve function.

Original languageEnglish
Title of host publicationUnknown Host Publication Title
PublisherAssoc for the Advancement of Medical Instrumentation
Pages40
Number of pages1
ISBN (Print)0910275343
Publication statusPublished - 1984

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ASJC Scopus subject areas

  • Engineering(all)

Cite this

Jones, M., Arbustini, E., Eidbo, E. E., & Ferrans, V. J. (1984). IN VIVO EXPERIMENTAL EVALUATION OF BIOPROSTHETIC CARDIAC VALVES. In Unknown Host Publication Title (pp. 40). Assoc for the Advancement of Medical Instrumentation.