In vivo image-guided MR thermometry during laser ablation: Experience in kidney and liver

Paola Saccomandi, Celine Giraudau, Federico Davrieux, Giuseppe Quero, Emiliano Schena, Luca Breschi, Francesco Maria Di Matteo, Guido Costamagna, Jacques Marescaux

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This works aims at assessing the thermal outcome of laser-based hyperthermia on living animals. Temperature evolution in target organs were monitored by means of non-invasive and contactless magnetic resonance (MR) images and fiber optic based-thermometers. Through MR-guidance, an expert interventional radiologist inserted MR-compatible fiber optic laser applicator and the thermometers through percutaneous procedure into kidney and liver. MR compatible, custom-made needle-like probes relying on fiber Bragg grating (FBG) technology were use to ease the percutaneous insertion of the thermometers into the organs. The thermal dependence of proton resonance frequency (PRF) of tissue water protons was used to obtain the MR thermal mapping; phase imaging method allowed the analysis of the thermal evolution. A respiratory-gated sequence was used to synchronize the images acquisition with the breathing frequency of the animal. The thermal maps provided by MR images were compared with the thermal trends measured by FBGs. Results showed that the temperature evolution measured by the FBGs at a specific distance from laser applicator tip was in accordance with the data provided by MR images, in both organs. Especially in liver, FBGs were subjected to the breathing movements (maximum error of 7 °C). Regarding MR thermometry, it was also subjected to some artifacts, mostly due to: 1) cavitation-induced phase shift in the images, and 2) breathing movements (temperature changes up to 10 °C). In conclusion, even though MR imaging is particularly useful for clinical applications, improvements still should be implemented in terms of motion compensation. The introduction of sensors in clinical practice can allows a safer evaluation of the temperature distribution, hence, of the induced thermal damage.

Original languageEnglish
Title of host publicationMeMeA 2018 - 2018 IEEE International Symposium on Medical Measurements and Applications, Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Print)9781538633915
DOIs
Publication statusPublished - Aug 16 2018
Event13th IEEE International Symposium on Medical Measurements and Applications, MeMeA 2018 - Rome, Italy
Duration: Jun 11 2018Jun 13 2018

Conference

Conference13th IEEE International Symposium on Medical Measurements and Applications, MeMeA 2018
CountryItaly
CityRome
Period6/11/186/13/18

Keywords

  • Fiber Bragg Grating sensors
  • laser ablation
  • MR thermometry
  • non-invasive temperature measurement

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Instrumentation

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