In vivo imaging of neuroinflammation

Annachiara Cagnin, Alexander Gerhard, Richard B. Banati

Research output: Contribution to journalArticle

Abstract

We briefly outline the rationale for employing positron emission tomography (PET), using the ligand [11C](R)-PK11195, the binding site for which is highly expressed by activated microglia, in order (a) to detect in vivo neuroinflammatory changes occurring in a variety of brain diseases and at different disease stages and (b) to monitor the progression of neuroinflammation as a generic in vivo marker of 'disease activity'. The use of [11C](R)-PK11195 PET is described as a systematic attempt at measuring the emerging phenomenology of tissue pathology itself - as opposed to measuring, for example, the loss of neuronal function or structure - and as a proof of principle for the clinical utility of imaging glial cells in vivo.

Original languageEnglish
Pages (from-to)581-586
Number of pages6
JournalEuropean Neuropsychopharmacology
Volume12
Issue number6
DOIs
Publication statusPublished - Dec 2002

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Keywords

  • [C](R)-PK11195
  • Neuroinflammation
  • Positron emission tomography

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neurology
  • Pharmacology
  • Psychology(all)

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