Abstract
The effect of thymopentin (TP-5) treatment on lymphocyte immune functions has been investigated in immunocompromized aged subjects. TP-5 was able to improve the cutaneous delayed hypersensitivity (CDH) to recall antigens and the proliferative response to phytohemagglutinin (PHA), concanavalin A, and Pokeweed (PWM) as well as the PHA-induced interleukin-2 (Il-2) production. On the other hand, no detectable changes were induced by TP-5 treatment either on PWM-induced immunoglobulin synthesis or on lymphocyte subsets identified by monoclonal antibodies. Our results suggest that the enhancement of Il-2 synthesis might be a crucial mechanism of the immunopharmacological action of TP-5 in aging humans.
| Original language | English |
|---|---|
| Pages (from-to) | 151-159 |
| Number of pages | 9 |
| Journal | Clinical Immunology and Immunopathology |
| Volume | 42 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1987 |
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ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Pathology and Forensic Medicine
Cite this
In vivo immunopotentiating activity of thymopentin in aging humans : Increase of Il-2 production. / Meroni, Pier Luigi; Barcellini, Wilma; Frasca, Daniela; Sguotti, Chiara; Borghi, M. Orietta; De Bartolo, Giovanni; Doria, Gino; Zanussi, Carlo.
In: Clinical Immunology and Immunopathology, Vol. 42, No. 2, 1987, p. 151-159.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vivo immunopotentiating activity of thymopentin in aging humans
T2 - Increase of Il-2 production
AU - Meroni, Pier Luigi
AU - Barcellini, Wilma
AU - Frasca, Daniela
AU - Sguotti, Chiara
AU - Borghi, M. Orietta
AU - De Bartolo, Giovanni
AU - Doria, Gino
AU - Zanussi, Carlo
PY - 1987
Y1 - 1987
N2 - The effect of thymopentin (TP-5) treatment on lymphocyte immune functions has been investigated in immunocompromized aged subjects. TP-5 was able to improve the cutaneous delayed hypersensitivity (CDH) to recall antigens and the proliferative response to phytohemagglutinin (PHA), concanavalin A, and Pokeweed (PWM) as well as the PHA-induced interleukin-2 (Il-2) production. On the other hand, no detectable changes were induced by TP-5 treatment either on PWM-induced immunoglobulin synthesis or on lymphocyte subsets identified by monoclonal antibodies. Our results suggest that the enhancement of Il-2 synthesis might be a crucial mechanism of the immunopharmacological action of TP-5 in aging humans.
AB - The effect of thymopentin (TP-5) treatment on lymphocyte immune functions has been investigated in immunocompromized aged subjects. TP-5 was able to improve the cutaneous delayed hypersensitivity (CDH) to recall antigens and the proliferative response to phytohemagglutinin (PHA), concanavalin A, and Pokeweed (PWM) as well as the PHA-induced interleukin-2 (Il-2) production. On the other hand, no detectable changes were induced by TP-5 treatment either on PWM-induced immunoglobulin synthesis or on lymphocyte subsets identified by monoclonal antibodies. Our results suggest that the enhancement of Il-2 synthesis might be a crucial mechanism of the immunopharmacological action of TP-5 in aging humans.
UR - http://www.scopus.com/inward/record.url?scp=0023088548&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023088548&partnerID=8YFLogxK
U2 - 10.1016/0090-1229(87)90002-X
DO - 10.1016/0090-1229(87)90002-X
M3 - Article
C2 - 3542319
AN - SCOPUS:0023088548
VL - 42
SP - 151
EP - 159
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
SN - 0090-1229
IS - 2
ER -