TY - JOUR
T1 - In vivo immunopotentiating activity of thymopentin in aging humans
T2 - Increase of Il-2 production
AU - Meroni, Pier Luigi
AU - Barcellini, Wilma
AU - Frasca, Daniela
AU - Sguotti, Chiara
AU - Borghi, M. Orietta
AU - De Bartolo, Giovanni
AU - Doria, Gino
AU - Zanussi, Carlo
PY - 1987
Y1 - 1987
N2 - The effect of thymopentin (TP-5) treatment on lymphocyte immune functions has been investigated in immunocompromized aged subjects. TP-5 was able to improve the cutaneous delayed hypersensitivity (CDH) to recall antigens and the proliferative response to phytohemagglutinin (PHA), concanavalin A, and Pokeweed (PWM) as well as the PHA-induced interleukin-2 (Il-2) production. On the other hand, no detectable changes were induced by TP-5 treatment either on PWM-induced immunoglobulin synthesis or on lymphocyte subsets identified by monoclonal antibodies. Our results suggest that the enhancement of Il-2 synthesis might be a crucial mechanism of the immunopharmacological action of TP-5 in aging humans.
AB - The effect of thymopentin (TP-5) treatment on lymphocyte immune functions has been investigated in immunocompromized aged subjects. TP-5 was able to improve the cutaneous delayed hypersensitivity (CDH) to recall antigens and the proliferative response to phytohemagglutinin (PHA), concanavalin A, and Pokeweed (PWM) as well as the PHA-induced interleukin-2 (Il-2) production. On the other hand, no detectable changes were induced by TP-5 treatment either on PWM-induced immunoglobulin synthesis or on lymphocyte subsets identified by monoclonal antibodies. Our results suggest that the enhancement of Il-2 synthesis might be a crucial mechanism of the immunopharmacological action of TP-5 in aging humans.
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U2 - 10.1016/0090-1229(87)90002-X
DO - 10.1016/0090-1229(87)90002-X
M3 - Article
C2 - 3542319
AN - SCOPUS:0023088548
VL - 42
SP - 151
EP - 159
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
SN - 0090-1229
IS - 2
ER -