In vivo immunopotentiating activity of thymopentin in aging humans: Increase of Il-2 production

Pier Luigi Meroni; Wilma Barcellini; Daniela Frasca; Chiara Sguotti; M. Orietta Borghi; Giovanni De Bartolo; Gino Doria; Carlo Zanussi

doi:10.1016/0090-1229(87)90002-X

In vivo immunopotentiating activity of thymopentin in aging humans: Increase of Il-2 production

Pier Luigi Meroni, Wilma Barcellini, Daniela Frasca, Chiara Sguotti, M. Orietta Borghi, Giovanni De Bartolo, Gino Doria, Carlo Zanussi

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of thymopentin (TP-5) treatment on lymphocyte immune functions has been investigated in immunocompromized aged subjects. TP-5 was able to improve the cutaneous delayed hypersensitivity (CDH) to recall antigens and the proliferative response to phytohemagglutinin (PHA), concanavalin A, and Pokeweed (PWM) as well as the PHA-induced interleukin-2 (Il-2) production. On the other hand, no detectable changes were induced by TP-5 treatment either on PWM-induced immunoglobulin synthesis or on lymphocyte subsets identified by monoclonal antibodies. Our results suggest that the enhancement of Il-2 synthesis might be a crucial mechanism of the immunopharmacological action of TP-5 in aging humans.

Original language	English
Pages (from-to)	151-159
Number of pages	9
Journal	Clinical Immunology and Immunopathology
Volume	42
Issue number	2
DOIs	https://doi.org/10.1016/0090-1229(87)90002-X
Publication status	Published - 1987

ASJC Scopus subject areas

Immunology
Immunology and Allergy
Pathology and Forensic Medicine

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10.1016/0090-1229(87)90002-X

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In vivo immunopotentiating activity of thymopentin in aging humans : Increase of Il-2 production. / Meroni, Pier Luigi ; Barcellini, Wilma; Frasca, Daniela; Sguotti, Chiara; Borghi, M. Orietta; De Bartolo, Giovanni; Doria, Gino; Zanussi, Carlo.

In: Clinical Immunology and Immunopathology, Vol. 42, No. 2, 1987, p. 151-159.

Research output: Contribution to journal › Article › peer-review

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title = "In vivo immunopotentiating activity of thymopentin in aging humans: Increase of Il-2 production",

abstract = "The effect of thymopentin (TP-5) treatment on lymphocyte immune functions has been investigated in immunocompromized aged subjects. TP-5 was able to improve the cutaneous delayed hypersensitivity (CDH) to recall antigens and the proliferative response to phytohemagglutinin (PHA), concanavalin A, and Pokeweed (PWM) as well as the PHA-induced interleukin-2 (Il-2) production. On the other hand, no detectable changes were induced by TP-5 treatment either on PWM-induced immunoglobulin synthesis or on lymphocyte subsets identified by monoclonal antibodies. Our results suggest that the enhancement of Il-2 synthesis might be a crucial mechanism of the immunopharmacological action of TP-5 in aging humans.",

author = "Meroni, {Pier Luigi} and Wilma Barcellini and Daniela Frasca and Chiara Sguotti and Borghi, {M. Orietta} and {De Bartolo}, Giovanni and Gino Doria and Carlo Zanussi",

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T2 - Increase of Il-2 production

AU - Meroni, Pier Luigi

AU - Barcellini, Wilma

AU - Frasca, Daniela

AU - Sguotti, Chiara

AU - Borghi, M. Orietta

AU - De Bartolo, Giovanni

AU - Doria, Gino

AU - Zanussi, Carlo

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AB - The effect of thymopentin (TP-5) treatment on lymphocyte immune functions has been investigated in immunocompromized aged subjects. TP-5 was able to improve the cutaneous delayed hypersensitivity (CDH) to recall antigens and the proliferative response to phytohemagglutinin (PHA), concanavalin A, and Pokeweed (PWM) as well as the PHA-induced interleukin-2 (Il-2) production. On the other hand, no detectable changes were induced by TP-5 treatment either on PWM-induced immunoglobulin synthesis or on lymphocyte subsets identified by monoclonal antibodies. Our results suggest that the enhancement of Il-2 synthesis might be a crucial mechanism of the immunopharmacological action of TP-5 in aging humans.

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In vivo immunopotentiating activity of thymopentin in aging humans: Increase of Il-2 production

Abstract

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