In vivo inhibition of human hepatocellular carcinoma related angiogenesis by vinblastine and rapamycin

Domenico Ribatti; B. Nico; D. Mangieri; V. Longo; D. Sansonno; A. Vacca; F. Dammacco

In vivo inhibition of human hepatocellular carcinoma related angiogenesis by vinblastine and rapamycin

Domenico Ribatti, B. Nico, D. Mangieri, V. Longo, D. Sansonno, A. Vacca, F. Dammacco

IRCCS Giovanni Paolo II

Research output: Contribution to journal › Article › peer-review

Abstract

This paper illustrates the use of the chick embryo chorioallantoic membrane (CAM) assay to determine the single and combined antiangiogenic effects of very low doses of vinblastine (VBL) and rapamycin (RAP) in human hepatocellular carcinoma (HCC). The angiogenic response induced by human HCC biopsy specimens was inhibited by each drug and sinergistically by their combination. Morever, immunohistochemical detection of microvessels with anti-CD31 mAB showed that their area was significantly lower in specimens treated with VBL and RAP in combination. Sinergy on the part of these well-known drugs when used in combination as antiangiogenics at very low doses may be of significance in the designing of new ways of treating HCC.

Original language	English
Pages (from-to)	285-289
Number of pages	5
Journal	Histology and Histopathology
Volume	22
Issue number	1-3
Publication status	Published - Jan 2007

Keywords

Antiangiogenesis
Hepatocellular carcinoma
Rapamycin
Tumor progression
Vessel growth
Vinblastine

ASJC Scopus subject areas

Anatomy
Pathology and Forensic Medicine
Histology
Cell Biology

Cite this

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abstract = "This paper illustrates the use of the chick embryo chorioallantoic membrane (CAM) assay to determine the single and combined antiangiogenic effects of very low doses of vinblastine (VBL) and rapamycin (RAP) in human hepatocellular carcinoma (HCC). The angiogenic response induced by human HCC biopsy specimens was inhibited by each drug and sinergistically by their combination. Morever, immunohistochemical detection of microvessels with anti-CD31 mAB showed that their area was significantly lower in specimens treated with VBL and RAP in combination. Sinergy on the part of these well-known drugs when used in combination as antiangiogenics at very low doses may be of significance in the designing of new ways of treating HCC.",

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AU - Ribatti, Domenico

AU - Nico, B.

AU - Mangieri, D.

AU - Longo, V.

AU - Sansonno, D.

AU - Vacca, A.

AU - Dammacco, F.

PY - 2007/1

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AB - This paper illustrates the use of the chick embryo chorioallantoic membrane (CAM) assay to determine the single and combined antiangiogenic effects of very low doses of vinblastine (VBL) and rapamycin (RAP) in human hepatocellular carcinoma (HCC). The angiogenic response induced by human HCC biopsy specimens was inhibited by each drug and sinergistically by their combination. Morever, immunohistochemical detection of microvessels with anti-CD31 mAB showed that their area was significantly lower in specimens treated with VBL and RAP in combination. Sinergy on the part of these well-known drugs when used in combination as antiangiogenics at very low doses may be of significance in the designing of new ways of treating HCC.

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KW - Hepatocellular carcinoma

KW - Rapamycin

KW - Tumor progression

KW - Vessel growth

KW - Vinblastine

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In vivo inhibition of human hepatocellular carcinoma related angiogenesis by vinblastine and rapamycin

Abstract

Keywords

ASJC Scopus subject areas

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