Abstract
Old ApoE-deficient mice were studied in vivo by magnetic resonance imaging (MRI) to prospectively evaluate vascular remodeling associated with atherosclerotic lesions. Material and Methods: Old female ApoE-/- mice on a normal diet were followed by MRI at 2 Tesla for a 3-month period and killed for histopathology. Aortic dimensions were measured and compared. Results: High-quality in vivo MR images were obtained at 2 Tesla with in plane spatial resolution of 86 x 86 μm2. On MRI, aortic lumen enlargement (>1.5-fold dilation) was seen in 10 of 13 mice, located predominantly in the suprarenal portion of the aorta. The mean maximal diameter of the aneurysms and of the aorta above and below the aneurysm were, respectively, 1.12±0.32 mm and 0.53±0.08 mm by MRI and 1.3±0.41 mm and 0.55±0.15 mm by histology. Matched histologic cross-sections of the aortic wall showed medial degradation with rupture of the internal elastic lamina at multiple sites, associated with fibrolipidic plaque containing cholesterol crystals. Conclusions: Aortic lumen enlargement was diagnosed in old ApoE-/- mice at sites with advanced atherosclerotic plaques. MRI has potential both as an in vivo imaging technique for screening mouse models for vascular wall pathology and to follow arterial remodeling associated with the disease progression.
| Original language | English |
|---|---|
| Pages (from-to) | 585-590 |
| Number of pages | 6 |
| Journal | Investigative Radiology |
| Volume | 39 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2004 |
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Keywords
- Aneurysms
- Apolipoprotein E knockout mice
- Atherosclerosis
- Magnetic resonance imaging
- Remodeling
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
In vivo magnetic resonance imaging of-large spontaneous aortic aneurysms in old apolipoprotein E-deficient mice. / McFadden, Eugène P.; Chaabane, Linda; Contard, Francis; Guerrier, Daniel; Briguet, André; Douek, Philippe; Soulas, Emmanuelle Canet.
In: Investigative Radiology, Vol. 39, No. 10, 10.2004, p. 585-590.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vivo magnetic resonance imaging of-large spontaneous aortic aneurysms in old apolipoprotein E-deficient mice
AU - McFadden, Eugène P.
AU - Chaabane, Linda
AU - Contard, Francis
AU - Guerrier, Daniel
AU - Briguet, André
AU - Douek, Philippe
AU - Soulas, Emmanuelle Canet
PY - 2004/10
Y1 - 2004/10
N2 - Old ApoE-deficient mice were studied in vivo by magnetic resonance imaging (MRI) to prospectively evaluate vascular remodeling associated with atherosclerotic lesions. Material and Methods: Old female ApoE-/- mice on a normal diet were followed by MRI at 2 Tesla for a 3-month period and killed for histopathology. Aortic dimensions were measured and compared. Results: High-quality in vivo MR images were obtained at 2 Tesla with in plane spatial resolution of 86 x 86 μm2. On MRI, aortic lumen enlargement (>1.5-fold dilation) was seen in 10 of 13 mice, located predominantly in the suprarenal portion of the aorta. The mean maximal diameter of the aneurysms and of the aorta above and below the aneurysm were, respectively, 1.12±0.32 mm and 0.53±0.08 mm by MRI and 1.3±0.41 mm and 0.55±0.15 mm by histology. Matched histologic cross-sections of the aortic wall showed medial degradation with rupture of the internal elastic lamina at multiple sites, associated with fibrolipidic plaque containing cholesterol crystals. Conclusions: Aortic lumen enlargement was diagnosed in old ApoE-/- mice at sites with advanced atherosclerotic plaques. MRI has potential both as an in vivo imaging technique for screening mouse models for vascular wall pathology and to follow arterial remodeling associated with the disease progression.
AB - Old ApoE-deficient mice were studied in vivo by magnetic resonance imaging (MRI) to prospectively evaluate vascular remodeling associated with atherosclerotic lesions. Material and Methods: Old female ApoE-/- mice on a normal diet were followed by MRI at 2 Tesla for a 3-month period and killed for histopathology. Aortic dimensions were measured and compared. Results: High-quality in vivo MR images were obtained at 2 Tesla with in plane spatial resolution of 86 x 86 μm2. On MRI, aortic lumen enlargement (>1.5-fold dilation) was seen in 10 of 13 mice, located predominantly in the suprarenal portion of the aorta. The mean maximal diameter of the aneurysms and of the aorta above and below the aneurysm were, respectively, 1.12±0.32 mm and 0.53±0.08 mm by MRI and 1.3±0.41 mm and 0.55±0.15 mm by histology. Matched histologic cross-sections of the aortic wall showed medial degradation with rupture of the internal elastic lamina at multiple sites, associated with fibrolipidic plaque containing cholesterol crystals. Conclusions: Aortic lumen enlargement was diagnosed in old ApoE-/- mice at sites with advanced atherosclerotic plaques. MRI has potential both as an in vivo imaging technique for screening mouse models for vascular wall pathology and to follow arterial remodeling associated with the disease progression.
KW - Aneurysms
KW - Apolipoprotein E knockout mice
KW - Atherosclerosis
KW - Magnetic resonance imaging
KW - Remodeling
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UR - http://www.scopus.com/inward/citedby.url?scp=4644374038&partnerID=8YFLogxK
U2 - 10.1097/01.rli.0000138089.98165.88
DO - 10.1097/01.rli.0000138089.98165.88
M3 - Article
C2 - 15377937
AN - SCOPUS:4644374038
VL - 39
SP - 585
EP - 590
JO - Investigative Radiology
JF - Investigative Radiology
SN - 0020-9996
IS - 10
ER -