In vivo magnetic resonance metabolic and morphofunctional fingerprints in experimental models of human ovarian cancer

Rossella Canese, Delia Mezzanzanica, Marina Bagnoli, Stefano Indraccolo, Silvana Canevari, Franca Podo, Egidio Iorio

Research output: Contribution to journalShort survey

Abstract

Epithelial ovarian cancer (EOC) is the gynecological malignancy with the highest death rate, characterized by frequent relapse and onset of drug resistance. Disease diagnosis and therapeutic follow-up could benefit from application of molecular imaging approaches, such as magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS), able to monitor metabolic and functional alterations and investigate the underlying molecular mechanisms. Here, we overview the quantitative alterations that occur during either orthotopic or subcutaneous growth of preclinical EOC models. A common feature of 1H MR spectra is the presence of a prominent peak due to total choline-containing metabolites (tCho), together with other metabolic alterations and MRI-detected morphofunctional patterns specific for different phenotypes. The tCho signal,already present at early stages of tumor growth, and changes of diffusion-weighted MRI parameters could serve as markers of malignancy and/or tumor response to therapy. The identification by MRS and MRI of biochemical and physiopathological fingerprints of EOC disease in preclinical models can represent a basis for further developments of non-invasive MR approaches in the clinical setting.

Original languageEnglish
Article number164
JournalFrontiers in Oncology
Volume6
Issue numberJUN
DOIs
Publication statusPublished - Jun 28 2016

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Keywords

  • ADC
  • Animal model
  • DWI
  • Epithelial ovarian cancer
  • Magnetic resonance spectroscopy
  • MRI
  • Target therapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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