In vivo metabolism and kinetics of99mTc-HMPAO

G. Lucignani, C. Rossetti, P. Ferrario, L. Zecca, M. C. Gilardi, F. Zito, D. Perani, G. L. Lenzi, F. Fazio

Research output: Contribution to journalArticlepeer-review


The cerebral distribution of99mTc-labeled d, l, hexamethyl-propylene-amine-oxime (99mTc-HMPAO) as a function of rCBF and time was examined in rats and in man. The results of this study confirm that99mTc-HMPAO is distributed in brain in proportion to rCBF. However, the rapid systemic breakdown of the tracer in blood results in considerable difficulties in the assessment of the arterial concentration of the parent compound; incomplete extraction of99mTc-HMPAO from blood to brain and significant efflux from brain represent further limitations in the use of this tracer for quantification of rCFB. Despite these limitations99mTc-HMPAO is of potential interest for a qualitative assessment of rCBF in specific clinical conditions.

Original languageEnglish
Pages (from-to)249-255
Number of pages7
JournalEuropean Journal Of Nuclear Medicine
Issue number4-6
Publication statusPublished - Apr 1990


  • Tc
  • Blood flow
  • Brain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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