In vivo model for mastocytosis: A comparative review

Girolamo Ranieri, Ilaria Marech, Marianna Pantaleo, Mariagrazia Piccinno, Maria Roncetti, Maddalena Mutinati, Annalisa Rizzo, Cosmo Damiano Gadaleta, Marcello Introna, Rosa Patruno, Raffaele Luigi Sciorsci

Research output: Contribution to journalArticle

Abstract

Human mastocytosis are heterogeneous group of neoplastic diseases characterized by a different degree of uncontrolled mast cell (MC) proliferation and activation. Interestingly, human mastocytosis share several biological and clinical features with canine mast cell disorders, so called canine mast cell tumors (CMCTs). These CMCTs are the most common spontaneous cutaneous tumors found in dogs representing a valid model to study neoplastic mast cell disorders. It has been discovered that the pathological activation of c-Kit receptor (c-KitR), expressed by MCs, has been involved in the pathogenesis of neoplastic MC disorders. In this review we have focused on human mastocytosis in terms of: (i) epidemiology and classification; (ii) pathogenesis at molecular levels; (iii) clinical presentation. In addition, we have summarized animal models useful to study neoplastic MC disorders including CMCTs and murine transgenic models. Finally, we have revised therapeutic approaches mostly common in human and canine MCTs and novel tyrosine kinase inhibitors approved for CMCTs and recently translated in human clinical trials.

Original languageEnglish
Pages (from-to)159-169
Number of pages11
JournalCritical Reviews in Oncology/Hematology
Volume93
Issue number3
DOIs
Publication statusPublished - Mar 1 2015

Keywords

  • Animal mast cell tumors
  • C-Kit receptor
  • Human mastocytosis
  • Tyrosine kinase inhibitors (TKIs)

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Geriatrics and Gerontology
  • Medicine(all)

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    Ranieri, G., Marech, I., Pantaleo, M., Piccinno, M., Roncetti, M., Mutinati, M., Rizzo, A., Gadaleta, C. D., Introna, M., Patruno, R., & Sciorsci, R. L. (2015). In vivo model for mastocytosis: A comparative review. Critical Reviews in Oncology/Hematology, 93(3), 159-169. https://doi.org/10.1016/j.critrevonc.2014.10.010